A Case of Hallopeau Type Pemphigus Vegetans Successfully Treated with High-dose Intravenous Immunoglobulin(IVIG)Therapy

DOI Web Site Web Site Open Access
  • YAGI Nobutake
    Department of Dermatology, Okinawa Prefectural Nanbu Medical Center & Children's Medical Center
  • YAMAGUCHII Sayaka
    Department of Dermatology, Graduate School of Medicine, University of the Ryukyus
  • TAKAHASHI Kenzo
    Department of Dermatology, Graduate School of Medicine, University of the Ryukyus

Bibliographic Information

Other Title
  • 免疫グロブリン大量静注療法(IVIG)が著効した Hallopeau 型増殖性天疱瘡の 1 例
  • 症例 免疫グロブリン大量静注療法(IVIG)が著効したHallopeau型増殖性天疱瘡の1例
  • ショウレイ メンエキ グロブリン タイリョウ ジョウチュウ リョウホウ(IVIG)ガ チョコウシタ Hallopeauガタ ゾウショクセイ テンポウソウ ノ 1レイ

Search this article

Abstract

<p>An 83-year-old woman had complained of pain of her genital region for one month. She was suspected of having a malignant tumor at a nearby clinic and was admitted to our hospital for further examination. At her first visit, verrucous vegetation was seen on the entire genital region. After a limited time, erosions at the axilla and lips and thickening of the tongue also appeared. Histologically, acanthosis and a microabscess containing numerous eosinophils were observed at the lesional epidermis. Direct immunofluorescence analysis revealed the deposition of IgG at keratinocyte surfaces. Her serum levels of anti-desmoglein (Dsg) 1 and anti-Dsg3 antibodies were elevated. Based on clinical, histological, and laboratory findings, this case was diagnosed as Hallopeau type pemphigus vegetans. Although she developed a widespread erosion that was not well controlled with oral corticosteroids only, the erosion was controlled by combining corticosteroids with high-dose intravenous immunoglobulin therapy.</p>

Journal

  • Nishi Nihon Hifuka

    Nishi Nihon Hifuka 79 (6), 552-557, 2017

    Western Division of Japanese Dermatological Association

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top