Patients’ Characteristics and Clinical Course of Hypertrophic Cardiomyopathy in a Regional Japanese Cohort ― Results From Kochi RYOMA Study ―
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- Kubo Toru
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
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- Hirota Takayoshi
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
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- Baba Yuichi
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
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- Ochi Yuri
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
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- Takahashi Asa
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
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- Yamasaki Naohito
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
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- Hamashige Naohisa
- Department of Cardiology, Chikamori Hospital
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- Yamamoto Katsuhito
- Department of Cardiology, Kochi Health Sciences Center
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- Kondo Fumiaki
- Department of Cardiology, Japanese Red Cross Kochi Hospital
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- Bando Kanji
- Department of Cardiology, Tosa Municipal Hospital
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- Yamada Eisuke
- Department of Cardiology, Susaki Kuroshio Hospital
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- Furuno Takashi
- Department of Cardiology, Kochi Prefectural Aki General Hospital
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- Yabe Toshikazu
- Department of Cardiology, Kochi Prefectural Hata Kenmin Hospital
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- Doi Yoshinori L
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University Department of Cardiology, Chikamori Hospital
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- Kitaoka Hiroaki
- Department of Cardiology and Geriatrics, Kochi Medical School, Kochi University
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Abstract
<p>Background:There have been few studies on the clinical course of hypertrophic cardiomyopathy (HCM) in a community-based patient cohort in Japan.</p><p>Methods and Results:In 2004, we established a cardiomyopathy registration network in Kochi Prefecture (the Kochi RYOMA study) that consisted of 9 hospitals, and finally, 293 patients with HCM were followed. The ages at registration and at diagnosis were 63±14 and 56±16 years, respectively, and 197 patients (67%) were male. HCM-related deaths occurred in 23 patients during a mean follow-up period of 6.1±3.2 years. The HCM-related 5-year survival rate was 94%. In addition, a total of 77 cardiovascular events that were clinically severe occurred in 70 patients, and the HCM-related 5-year event-free rate was 80%. Multivariate Cox proportional hazards model analysis showed that the presence of NYHA class III at registration was a significant predictor of HCM-related deaths and that the presence of atrial fibrillation, lower fractional shortening and presence of left ventricular outflow tract obstruction in addition to NYHA class III were significant predictors of cardiovascular events.</p><p>Conclusions:In our unselected registry in an aged Japanese community, HCM mortality was favorable, but one-fifth of the patients commonly suffered from HCM-related adverse cardiovascular events during the 5-year follow-up period. Careful management of HCM patients is needed, particularly for those with the above-mentioned clinical determinants.</p>
Journal
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- Circulation Journal
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Circulation Journal 82 (3), 824-830, 2018
The Japanese Circulation Society
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Details 詳細情報について
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- CRID
- 1390001205108166272
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- NII Article ID
- 130006394496
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- NII Book ID
- AA11591968
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- ISSN
- 13474820
- 13469843
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- NDL BIB ID
- 028850183
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- PubMed
- 29332907
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed