Palliative Reirradiation for Painful Bone Metastases: Clinical Cases and Literature Review

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Author(s)

    • SUZUKI GEN
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • NAKASHIMA AKIHIRO
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • YAMADA KEI
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • YAMAZAKI HIDEYA
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • AIBE NORIHIRO
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • MASUI KOJI
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • SASAKI NAOMI
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • TATEKAWA KOTOHA
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • SHIMIZU DAISUKE
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • KIMOTO TAKUYA
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine
    • NISHIMURA TAKESHI
    • Department of Radiology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine

Abstract

<p><b>Summary: </b>Reirradiation to previously irradiated peripheral bone metastases for pain has been shown to be safe and effective, but no specific trial has been completed to define the indications for reirradiation of patients with recurrent symptoms of metastatic bone disease. Thus, we aimed to assess the effectiveness and prognostic factors of reirradiation for painful bone metastases. To do so, we reviewed the cases of 14 patients with painful bone metastases who had undergone reirradiation at our hospital. A favorable pain response after reirradiation was achieved in 50% (7/14) of the patients. An interval from initial radiotherapy >6 months was a significant prog nostic factor for pain response (<i>p</i> = 0.03). Performance status was correlated with pain response, with borderline significance (<i>p</i> = 0.06). No severe adverse events were reported. We conclude that reirradiation of painful bone metastases is effective in providing pain relief, especially for patients with a long interval from initial radiation and good performance status.</p>

Journal

  • The Kurume Medical Journal

    The Kurume Medical Journal 64(1.2), 5-11, 2017

    Kurume University School of Medicine

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