Effect of prenatal administration of low dose antibiotics on gut microbiota and body fat composition of newborn mice

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Author(s)

    • Yoshimoto Ayumi
    • Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University
    • Uebanso Takashi
    • Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University
    • Nakahashi Mutsumi
    • Graduate School of Technology, Industrial and Social Sciences, Tokushima University
    • Shimohata Takaaki
    • Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University
    • Mawatari Kazuaki
    • Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University
    • Takahashi Akira
    • Department of Preventive Environment and Nutrition, Institute of Biomedical Sciences, Tokushima University

Abstract

<p>Several environmental factors during the prenatal period transgenerationally affect the health of newborns in later life. Because low-dose antibiotics have been used for promoting the growth of crops and livestock in agriculture, humans may have ingested residual antibiotics for several decades. However, the effect of prenatal administration of low-dose antibiotics on newborns' health in later life is unclear. In the present study, we found that prenatal treatment of murine mothers with low-dose antibiotics increased the abundance of bacteria of the phylum <i>Firmicutes</i> and the genera <i>Clostridium IV</i> and <i>XIVa</i> in feces from pups. In addition, the body fat percentage of mice in the antibiotic-treated group was higher than those in the control group at 12 weeks of age even though all pups were fed a standard diet. The body fat percentage of all mice was correlated with the abundance of fecal bacteria of <i>Clostridium IV</i> and <i>XIVa</i>. These results predict that low-dose antibiotic administration during the prenatal period affects the gut microbiota of newborns and possibly their health in later life.</p>

Journal

  • Journal of Clinical Biochemistry and Nutrition

    Journal of Clinical Biochemistry and Nutrition 62(2), 155-160, 2018

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Codes

  • NII Article ID (NAID)
    130006407472
  • Text Lang
    ENG
  • ISSN
    0912-0009
  • Data Source
    J-STAGE 
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