Preventive effect of <i>Dioscorea japonica</i> on squamous cell carcinoma of mouse skin involving down-regulation of prostaglandin E<sub>2</sub> synthetic pathway

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Author(s)

    • Miki Yoshimi
    • Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science|Laboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo
    • Murakami Makoto
    • Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science|Laboratory of Microenvironmental and Metabolic Health Sciences, Center for Disease Biology and Integrative Medicine, Faculty of Medicine, The University of Tokyo|AMED-CREST, Japan Agency for Medical Research and Development
    • Toda Keisuke
    • Department of Nutritional Science, Okayama Prefectural University
    • Mega Takuto
    • Department of Nutritional Science, Okayama Prefectural University
    • Tanaka Mitsuki
    • Department of Nutritional Science, Okayama Prefectural University
    • Kawakami Yuki
    • Department of Nutritional Science, Okayama Prefectural University
    • Kimoto Masumi
    • Department of Nutritional Science, Okayama Prefectural University
    • Yamamoto Kei
    • Lipid Metabolism Project, Tokyo Metropolitan Institute of Medical Science|Graduate School of Technology, Industrial and Social Science, Tokushima University|PRIME, Japan Agency for Medical Research and Development

Abstract

<p>Hyperproduced prostaglandin E<sub>2</sub> by cyclooxygenase-2 and microsomal prostaglandin E synthase-1 evokes several pathophysiological responses such as inflammation and carcinogenesis. Our recent study demonstrated that <i>Dioscorea japonica</i> extract suppressed the expression of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 and induced apoptosis in lung carcinoma A549 cells. In the present study, we investigated the effects of <i>Dioscorea japonica</i> on squamous cell carcinoma of mouse skin. <i>Dioscorea japonica</i> feeding and <i>Dioscorea japonica</i> extract topical application suppressed the expression of cyclooxygenase-2, microsomal prostaglandin E synthase-1, interleukin-1β and interleukin-6 and inhibited tumor formation, hyperplasia and inflammatory cell infiltration. Immunohistochemical analyses showed the immunoreactivities of cyclooxygenase-2 and microsomal prostaglandin E synthase-1 in tumor keratinocytes and stronger immunoreactivities of cyclooxygenase-2 and hematopoietic prostaglandin D synthase in epidermal dendritic cells (Langerhans cells). Treatment with <i>Dioscorea japonica</i> decreased the immunoreactivity of cyclooxygenase-2 and microsomal prostaglandin E synthase-1. These results indicate that <i>Dioscorea japonica</i> may have inhibitory effects on inflammation and carcinogenesis via suppression of the prostaglandin E<sub>2</sub> synthetic pathway.</p>

Journal

  • Journal of Clinical Biochemistry and Nutrition

    Journal of Clinical Biochemistry and Nutrition 62(2), 139-147, 2018

    SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Codes

  • NII Article ID (NAID)
    130006407477
  • Text Lang
    ENG
  • ISSN
    0912-0009
  • Data Source
    J-STAGE 
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