Dietary intake of inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus
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- Kawamura Hiromi
- Graduate School of Human Science and Environment, University of Hyogo
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- Tanaka Sarasa
- School of Human Science and Environment, University of Hyogo
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- Ota Yuri
- School of Human Science and Environment, University of Hyogo
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- Endo Sumire
- School of Human Science and Environment, University of Hyogo
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- Tani Mariko
- Graduate School of Human Science and Environment, University of Hyogo
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- Ishitani Midori
- Graduate School of Human Science and Environment, University of Hyogo
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- Sakaue Motoyoshi
- Graduate School of Human Science and Environment, University of Hyogo
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- Ito Mikiko
- Graduate School of Human Science and Environment, University of Hyogo
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Abstract
<p>Phosphorus management through dietetic therapy is vital for the prevention of cardiovascular disease in chronic kidney disease patients. There are two main sources of phosphorus in the diet, organic phosphorus from protein and inorganic phosphorus from food additives. The adverse effects of high phosphorus intake on vascular-endothelium function have been reported; however, the differences in the effects of organic phosphorus versus inorganic phosphorus are not clear. In this study, we examined an acute effect of these high phosphorus meals intake on vascular-endothelium function. This was a randomized, double-blind, cross-over test study design targeting healthy young men. We conducted a food intake test using two test meals, one high in organic phosphorus from organic food sources, and one high in inorganic phosphorus from food additives. Endothelium-dependent vasodilation, phosphorus and calcium in the urine and blood, and phosphorus-related hormones were measured preprandial to 120 min postprandial. The results showed higher serum and urine phosphorus values after the high inorganic phosphorus meal, and a significant reduction in endothelium-dependent vasodilation at 30 min postprandial. These findings are evidence that inorganic phosphorus has a stronger influence on vascular-endothelium function than organic phosphorus.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 62 (2), 167-173, 2018
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Details 詳細情報について
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- CRID
- 1390282679650135552
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- NII Article ID
- 130006407515
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed