Evaluation of Dispersibility in Liquid and AC Magnetization Properties of Polyion Complex-Coupled Magnetic Nanoparticles

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Abstract

<p>  Medical applications such as those using magnetic nanoparticles (MNPs) for hyperthermia and magnetic particle imaging (MPI) require suitably designed particles with distinct characteristics. However, it is challenging to develop such particles with a high degree of biocompatibility. In this study, a cationic diblock copolymer (PMPC<sub>100</sub>-<i>b</i>-MMAPTAC<sub>100</sub>: P<sub>100</sub>M<sub>100</sub>) composed of poly(2-(methacryloyloxy)ethyl phosphorylcholine) (PMPC) and poly(3-(methacryloylamino)propyl trimethylammonium chloride) (PMAPTAC) was synthesized via a controlled radical polymerization technique to obtain particles with high biocompatibility and antithrombogenicity. Magnetic polyion complex (PIC) aggregate (M-300/P<sub>100</sub>M<sub>100</sub>) is an aggregate of magnetic Fe<sub>3</sub>O<sub>4</sub> nanoparticles (M-300), in which their anionic surface is electrostatically coated with cationic PMPC<sub>100</sub>-<i>b</i>-MMAPTAC<sub>100</sub> (P<sub>100</sub>M<sub>100</sub>). We investigated the stability of the magnetic PIC aggregate in an ionic solution by evaluating the relationship between the particle diameter and salt concentration. We then estimated the intrinsic loss power (ILP) from the areas of the alternating current (AC) hysteresis loops and measured the AC magnetization of the magnetic PIC aggregate. The peak frequencies from the Brownian relaxation of M-300 and M-300/P<sub>100</sub>M<sub>100</sub> were 9 kHz and 245 Hz, respectively. When the third harmonic was evaluated for use in MPI, the signal intensity was found to be comparable to that of M-300 in a fixed state.</p>

Journal

  • Journal of the Magnetics Society of Japan

    Journal of the Magnetics Society of Japan 42(2), 41-48, 2018

    The Magnetics Society of Japan

Codes

  • NII Article ID (NAID)
    130006407899
  • NII NACSIS-CAT ID (NCID)
    AA12297999
  • Text Lang
    ENG
  • ISSN
    1882-2924
  • NDL Article ID
    028836474
  • NDL Call No.
    YH247-1531
  • Data Source
    NDL  J-STAGE 
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