EFFECT OF URACIL AND ITS DERIVATIVES ON ANTITUMOR ACTIVITY OF 5-FLUOROURACIL AND 1-(2-TETRAHYDROFURYL)-5-FLUOROURACIL
書誌事項
- タイトル別名
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- Effect of Uracil and Its Derivatives on
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Uracil prevented the growth inhibition of Staphylococcus aureus 209P by 5-fluorouracil (5-FU). However, uracil did not reverse the growth inhibition by 5-FU in mammalian FM3A/B and HeLa cells even at 1, 000 times the concentration of 5-FU. These findings suggested that co-administration of uracil or its derivatives with 5-FU or the 5-FU derivative, 1-(2-tetrahydrofuryl)-5-fluo-rouracil (FT-207), might prevent the degradation of 5-FU released from FT-207 and thus increase the antitumor activity of FT-207. It was found that the antitumor activity of FT-207 on sarcoma-180 and AH-130 tumor was enhanced by oral administration of uracil, dUrd, or Urd. This enhancement of the antitumor activity of FT-207 increased with the dose of uracil. Uracil caused more enhancement than did dUrd or Urd.<br>The correlation between the doses of FT-207 and uracil, and the 5-FU levels in the tumor and blood was studied. When appropriate dose of uracil was co-administered with 3H-FT-207, 5-FU levels in the tumor became much higher than when FT-207 was administered alone and reduced very slowly, while that in the blood rapidly decreased. Consequently, the ratio of 5-FU level in the tumor to that in the blood increased markedly.<br>Co-administration of 5-FU and uracil increased the 5-FU levels in the blood and tumor to almost the same extent and the ratio of these levels was less than that after administration of 5-FU. These findings suggest that, in contrast to the results with FT-207, co-administration of uracil with 5-FU increased its antitumor activity and also the toxicity of 5-FU.
収録刊行物
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- GANN Japanese Journal of Cancer Research
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GANN Japanese Journal of Cancer Research 69 (6), 763-772, 1978
日本癌学会
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詳細情報 詳細情報について
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- CRID
- 1390282680507352704
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- NII論文ID
- 130006409831
- 10012274288
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- NII書誌ID
- AN00045888
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- NDL書誌ID
- 2075757
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- ISSN
- 0016450X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可