Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin

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Author(s)

    • TATEYAMA Akito
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • MAYUMI Kayoko
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • SUGAYA Tsutomu
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • KATO Akihito
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • MIYAJI Hirofumi
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • NISHIDA Erika
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • IWASAKI Yasuhiko
    • Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan
    • FUJII Syuji
    • Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology, Osaka, Japan|Nanomaterials Microdevices Research Center, Osaka Institute of Technology, Osaka, Japan
    • KAWAMOTO Kohei
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • SHITOMI Kanako
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
    • FURIHATA Tomokazu
    • Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan

Abstract

<p>To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects.</p><p>Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering.</p>

Journal

  • Nano Biomedicine

    Nano Biomedicine 9(2), 69-76, 2017

    Nano Biomedical Society

Codes

  • NII Article ID (NAID)
    130006415678
  • NII NACSIS-CAT ID (NCID)
    AA12510316
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1883-5198
  • Data Source
    IR  J-STAGE 
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