Bone Induction by α-tricalcium Phosphate Microparticle Emulsion Containing Simvastatin

DOI HANDLE Open Access
  • TATEYAMA Akito
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • KATO Akihito
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • MIYAJI Hirofumi
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • NISHIDA Erika
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • IWASAKI Yasuhiko
    Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, Osaka, Japan
  • FUJII Syuji
    Department of Applied Chemistry, Faculty of Engineering, Osaka Institute of Technology, Osaka, Japan Nanomaterials Microdevices Research Center, Osaka Institute of Technology, Osaka, Japan
  • KAWAMOTO Kohei
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • SHITOMI Kanako
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • FURIHATA Tomokazu
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • MAYUMI Kayoko
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan
  • SUGAYA Tsutomu
    Department of Periodontology and Endodontology, Division of Oral Health Science, Faculty of Dental Medicine, Hokkaido University, Sapporo, Japan

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Abstract

<p>To improve the degradability and operability of conventional bone graft materials, we fabricated a water-oil emulsion based on α-tricalcium phosphate (α-TCP) bone paste. Simvastatin, a lipophilic hyperlipidemia treatment agent, reportedly enhances the expression of bone morphogenetic protein-2 and subsequent bone formation. Accordingly, we assessed the bone forming effects of α-TCP bone-paste containing simvastatin in rat cranial bone defects.</p><p>Bone paste exhibited porous structure and generation of hydroxyapatite after solidification. X-ray image analysis and histological examination were carried out after implantation of bone paste into rat skull defect. The results showed that new bone was formed after implantation of bone paste containing simvastatin. In particular, bone volume in the 0.1 mg simvastatin group was significantly promoted when compared to controls (no implantation). No bone paste residue was observed in the bone defect at 4 weeks after surgery. Therefore, α-TCP bone paste containing simvastatin is degradable and beneficial for bone tissue engineering.</p>

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