Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study: The Hokkaido Study on Environment and Children’s Health
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- Hanaoka Tomoyuki
- Hokkaido University Center for Environmental and Health Sciences
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- Tamura Naomi
- Hokkaido University Center for Environmental and Health Sciences Graduate School of Health Sciences, Hokkaido University
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- Ito Kumiko
- Hokkaido University Center for Environmental and Health Sciences Graduate School of Medicine, Hokkaido University
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- Sasaki Seiko
- Hokkaido University Center for Environmental and Health Sciences Graduate School of Medicine, Hokkaido University
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- Araki Atsuko
- Hokkaido University Center for Environmental and Health Sciences
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- Ikeno Tamiko
- Hokkaido University Center for Environmental and Health Sciences
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- Miyashita Chihiro
- Hokkaido University Center for Environmental and Health Sciences
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- Ito Sachiko
- Hokkaido University Center for Environmental and Health Sciences
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- Minakami Hisanori
- Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine
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- Cho Kazutoshi
- Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine
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- Endo Toshiaki
- Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University
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- Baba Tsuyoshi
- Department of Obstetrics and Gynecology, School of Medicine, Sapporo Medical University
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- Miyamoto Toshinobu
- Department of Obstetrics and Gynecology, Asahikawa Medical University
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- Sengoku Kazuo
- Department of Obstetrics and Gynecology, Asahikawa Medical University
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- Kishi Reiko
- Hokkaido University Center for Environmental and Health Sciences
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Abstract
<p>Background: Prevalence rates of all anomalies classified as birth defects, including those identified before the 22nd gestational week, are limited in published reports, including those from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). In our birth cohort study, we collected the data for all birth defects after 12 weeks of gestation.</p><p>Methods: Subjects in this study comprised 19,244 pregnant women who visited one of 37 associated hospitals in the Hokkaido Prefecture from 2003 through 2012, and completed follow-up. All birth defects after 12 weeks of gestation, including 55 marker anomalies associated with environmental chemical exposures, were recorded. We examined parental risk factors for birth defects and the association between birth defects and risk of growth retardation.</p><p>Results: Prevalence of all birth defects was 18.9/1,000 births. The proportion of patients with birth defects delivered between 12 and 21 weeks of gestation was approximately one-tenth of all patients with birth defects. Among those with congenital malformation of the nerve system, 39% were delivered before 22 weeks of gestation. All patients with anencephaly and encephalocele were delivered before 22 weeks of gestation. We observed different patterns of parental risk factors between birth defect cases included in ISBDSR and cases not included. Cases included in ISBDSR were associated with an increased risk of preterm birth. Cases not included in ISBDSR were associated with an increased risk of being small for gestational age at term.</p><p>Conclusions: Data from our study complemented the data from ICBDSR. We recommend that birth defects not included in ICBDSR also be analyzed to elucidate the etiology of birth defects.</p>
Journal
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- Journal of Epidemiology
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Journal of Epidemiology 28 (3), 125-132, 2018
Japan Epidemiological Association
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Details 詳細情報について
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- CRID
- 1390001204475713920
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- NII Article ID
- 130006434072
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- ISSN
- 13499092
- 09175040
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- HANDLE
- 2115/70869
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- PubMed
- 29093352
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- Text Lang
- en
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- Data Source
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed