下咽頭扁平上皮癌放射線治療後の原発残存・再発病変に対する救済手術症例の検討  [in Japanese] Salvage surgery for local recurrence of hypopharyngeal squamous cell carcinoma after definitive radiotherapy or chemoradiotherapy or bioradiotherapy  [in Japanese]

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Author(s)

    • 高橋 剛史 Takahashi Takeshi
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 蛯名 彩 Ebina Aya
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 日高 竜太 Hidaka Ryuta
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 服部 雅優 Hattori Masakatsu
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 坂井 利彦 Sakai Toshihiko
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 市川 千恭 Ichikawa Kazunori
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 永井 遼斗 Nagai Ryoto
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 西嶌 嘉容 Nishijima Yoshikata
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 佐々木 徹 Sasaki Toru
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 三谷 浩樹 Mitani Hiroki
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 川端 一嘉 Kawabata Kazuyoshi
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 米川 博之 Yonekawa Hiroyuki
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 福島 啓文 Fukushima Hirofumi
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 新橋 渉 Shinbashi Wataru
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 瀬戸 陽 Seto Akira
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research
    • 神山 亮介 Kamiyama Ryosuke
    • がん研究会有明病院頭頸科 Department of Head and Neck Oncology, Cancer Institute Hospital of Japanese Foundation for Cancer Research

Abstract

(化学)放射線治療後の原発残存・再発に対し救済手術を施行した下咽頭癌症例について,救済手術法の選択と合併症,予後につき,自験例について検討を行った。<br>2005年から2014年に下咽頭扁平上皮癌新鮮例のうち,170例に初回治療として根治的(化学)放射線治療を施行し,45例に原発残存・再発を認め,32例に救済手術を施行した。<br>救済術式は下咽頭喉頭全摘出術/下咽頭部分切除術/経口的切除:17/8/7例であり,術後観察期間は中央値23か月,術後3年生存率は71.3%であった。一方,術後合併症は18例(56.3%)で起きていた。救済手術は生命予後の改善に有用であり,症例を吟味し,各術式の得失を理解した上で,最適な術式を選択するべきと考えた。

This study presents the results of patients who underwent salvage surgery for local recurrence of hypopharyngeal squamous cell carcinoma (SCC) after definitive radiotherapy (RT), chemoradiotherapy (CRT) or bioradiotherapy (BRT). From 2005 to 2014, 170 patients with hypopharyngeal carcinoma were treated with definitive RT, CRT or BRT. Of the 45 patients (26.5%) who developed local recurrence, 32 underwent salvage surgery. The types of surgical procedures included total pharyngolaryngectomy (n=17), partial pharyngectomy (n=8), and transoral surgery (n=7).<br>The three-year overall survival rate of patients after the salvage surgery was 71.3%, with a median survival period of 23 months. Among these patients, postoperative complications occurred in 18 patients (56.3%).<br>Therefore, we conclude that salvage surgery is an effective treatment for improving the prognosis of patients with local recurrence of hypopharyngeal SCC, and it is important to understand all of the advantages and disadvantages of total pharyngolaryngectomy, partial pharyngectomy, and transoral surgery, in order to select an optimal treatment for each specific case.

Journal

  • JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY

    JOURNAL OF JAPAN SOCIETY FOR HEAD AND NECK SURGERY 27(3), 277-283, 2018

    JAPAN SOCIETY FOR HEAD AND NECK SURGERY

Codes

  • NII Article ID (NAID)
    130006496727
  • Text Lang
    JPN
  • ISSN
    1349-581X
  • Data Source
    J-STAGE 
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