Natural compounds that regulate lymph node sinus macrophages: Inducing an anti-tumor effect by regulating macrophage activation

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Author(s)

    • Fujiwara Yukio
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,
    • Saito Yoichi
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,
    • Shiota Takuya
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,
    • Cheng Pan
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,
    • Ikeda Tsuyoshi
    • Department of Natural Medicine, Faculty of Pharmaceutical Sciences, Sojo University, Kumamoto, Japan.
    • Ohnishi Koji
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,
    • Takeya Motohiro
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,
    • Komohara Yoshihiro
    • Department of Cell Pathology, Graduate School of Medical Sciences, Kumamoto University, Kumamoto, Japan,

Abstract

<p>Recent progress in anti-tumor therapy has revealed the significance of anti-tumor immune responses in tumor progression and clinical course in several kinds of malignant tumors. The draining lymph node is an important immune system component that contains a number of antigen-presenting cells, which induce rapid immune responses to foreign antigens. Current studies have shown that higher expression of CD169 on lymph node sinus macrophages is associated with the induction of anti-tumor immunity. In the present study, we searched for natural compounds that regulate the CD169-positive phenotype in macrophages to identify potential new anti-cancer agents targeting macrophage activation. Among 50 natural compounds, aculeatiside A, naringin, and onionin A significantly induced the CD169-positive phenotype in human monocyte-derived macrophages. These compounds also induced CD169 overexpression and secretion of inflammatory cytokines, including interleukin (IL)-1β and IL-12, in murine macrophages. Subcutaneous injection of aculeatiside A and naringin enhanced mRNA expression of IL-1β, IL12, and CD169 in regional lymph nodes in mice. These findings suggest aculeatiside A and naringin may enhance anti-tumor immune responses by inducing CD169-positive macrophages in lymph nodes.</p>

Journal

  • Journal of Clinical and Experimental Hematopathology

    Journal of Clinical and Experimental Hematopathology 58(1), 17-23, 2018

    The Japanese Society for Lymphoreticular Tissue Research

Codes

  • NII Article ID (NAID)
    130006512988
  • Text Lang
    ENG
  • ISSN
    1346-4280
  • Data Source
    J-STAGE 
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