Detection of Minimal Bone Marrow involvement of Blastic Plasmacytoid Dendritic Cell Neoplastic Cells - CD303 immunostaining as a diagnostic tool-
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- Ohe Rintaro
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Aung Naing Ye
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Shiono Yosuke
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Utsunomiya Aya
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Kabasawa Takanobu
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Tamazawa Nobuyuki
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Tamura Yuka
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Kato Tomoya
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Yamada Akane
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Hasegawa Shin
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Aizawa Keiko
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Inokura Kyoko
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Ito Satoshi
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Toubai Tomomi
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Kato Yuichi
- Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Tsunoda Takahiko
- Department of Dermatology, Yamagata City Hospital Saiseikan, Yamagata, Japan,
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- Onami Kosuke
- Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Suzuki Tamio
- Department of Dermatology, Yamagata University Faculty of Medicine, Yamagata, Japan,
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- Ishizawa Kenichi
- Department of Hematology and Cell Therapy, Yamagata University Faculty of Medicine, Yamagata, Japan
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- Yamakawa Mitsunori
- Department of Pathological Diagnostics, Yamagata University Faculty of Medicine, Yamagata, Japan,
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Abstract
<p>Blastic plasmacytoid dendritic cell (pDC) neoplasm (BPDCN) is a relatively rare hematological malignancy with significantly complex clinicopathological features that are still unclear. This study aimed to analyze the clinicopathological data of BPDCN and evaluate immunohistochemical detection of minimal bone marrow (BM) involvement. In this study, we examined skin and BM lesions from 6 patients with BPDCN. Neoplastic cells tested positive for CD303 (polyclonal, 100%; monoclonal, 40%) in the skin lesions and for CD303 (polyclonal, 100%; monoclonal, 67%) in the BM clots. Although immunostaining of CD4, CD56, CD123, CD303, and TCLl detected minimal BM involvement in 3 patients, morphological identification was challenging in the BM clots stained with hematoxylin–eosin. In conclusion, our results demonstrate the significance of observing BM smears to detect neoplastic cells and that immunohistochemical examination, including CD303 antibodies, is useful to detect minimal BM involvement. This study is the first to report the expression of thymic stromal lymphopoietin (TSLP) and its receptor in BPDCN cells. Therefore, the TSLP/TSLP receptor axis may be associated with the proliferation of BPDCN, and consequently, the survival of patients.</p>
Journal
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- Journal of Clinical and Experimental Hematopathology
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Journal of Clinical and Experimental Hematopathology 58 (1), 1-9, 2018
The Japanese Society for Lymphoreticular Tissue Research
