Clinical management and outcomes of completely resected stage I follicular lymphoma

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Author(s)

    • Yokohama Akihiko
    • Blood Transfusion Service, Gunma University Hospital, Faculty of Medicine, Gunma University, Maebashi, Gunma, Japan,
    • Koiso
    • Department of Hematology, Gunma University Graduate School of Medicine,
    • Saitoh Takayuki
    • Gunma University Graduate School of Health Sciences, Maebashi, Gunma, Japan,
    • Murayama Kayoko
    • Division of Hematology and Oncology, Gunma Cancer Center, Ohta, Gunma, Japan,
    • Matsumoto Morio
    • Division of Hematology, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan,
    • Sawamura Morio
    • Division of Hematology, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan,
    • Murakami Hirokazu
    • Gunma University Graduate School of Health Sciences, Maebashi, Gunma, Japan,
    • Hirato Junko
    • Clinical Department of Pathology, Gunma University Hospital, Maebashi, Gunma, Japan,
    • Kojima Masaru
    • Anatomic and Diagnostic Pathology, Dokkyo University School of Medicine, Mibu, Tochigi, Japan,
    • Nojima Yoshihisa
    • Department of Hematology, Gunma University Graduate School of Medicine,
    • Hashimoto Yoko
    • Department of Hematology, Gunma University Graduate School of Medicine,
    • Handa Hiroshi
    • Department of Hematology, Gunma University Graduate School of Medicine,
    • Takizawa Makiko
    • Department of Hematology, Gunma University Graduate School of Medicine,
    • Shimizu Hiroaki
    • Department of Hematology, Gunma University Graduate School of Medicine,
    • Miyazawa Yuri
    • Division of Hematology, National Hospital Organization Shibukawa Medical Center, Shibukawa, Gunma, Japan,
    • Saitoh Akio
    • Department of Hematology, Fujioka General Hospital, Fujioka, Gunma, Japan,
    • Toyama Kohtaro
    • Department of Hematology, Fujioka General Hospital, Fujioka, Gunma, Japan,
    • Ishizaki Takuma
    • Department of Hematology, Gunma University Graduate School of Medicine,
    • Mitsui Takeki
    • Department of Hematology, Gunma University Graduate School of Medicine,

Abstract

<p>Recent studies have revealed the clinical and biological features of stage I follicular lymphoma (FL), but information about patients with stage I FL who underwent total resection after tissue biopsy is limited. Among 305 FL patients diagnosed between 2001 and 2013, clinical stage I disease was observed in 36 patients. Of these, 18 patients underwent total resection after diagnostic tissue biopsy. We used <sup>18</sup>F-fluorodeoxyglucose positron emission CT for staging assessment in 13 of 18 patients (72.2%). The median age was 56.5 years. Six patients (33.3%) were male. The soluble interleukin-2 receptor alpha concentration was significantly lower than in patients with residual disease. Among these 18 patients, 7 patients (38.9%) were treated with a "watch-and-wait" (WW) policy, 7 (38.9%) were treated with involved-field irradiation, and 4 (22.2%) received systemic chemotherapy. Patients with resected disease were treated with significantly different strategies from those with residual disease (<i>p</i> = 0.0026). Five patients experienced relapse during follow-up (median follow-up: 48.2 months). All relapses were distant from the primary site, irrespective of treatment strategy. Among all stage I patients, disease resection was not a significant factor for survival (<i>p</i> = 0.9294). Collectively, the choice of treatment strategy was significantly influenced by patient status. Resection status was not significantly associated with survival after several treatment strategies.</p>

Journal

  • Journal of Clinical and Experimental Hematopathology

    Journal of Clinical and Experimental Hematopathology 58(1), 10-16, 2018

    The Japanese Society for Lymphoreticular Tissue Research

Codes

  • NII Article ID (NAID)
    130006512993
  • Text Lang
    ENG
  • ISSN
    1346-4280
  • Data Source
    J-STAGE 
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