Treatment Patterns, Statin Intolerance, and Subsequent Cardiovascular Events Among Japanese Patients With High Cardiovascular Risk Initiating Statin Therapy

• Nagar Saurabh P.

  RTI Health Solutions

• Rane Pratik P.

  Amgen Inc.

• Fox Kathleen M.

  Strategic Healthcare Solutions, LLC

• Meyers Juliana

  RTI Health Solutions

• Davis Keith

  RTI Health Solutions

• Beaubrun Anne

  Amgen Inc.

• Inomata Hyoe

  Amgen Astellas BioPharma K. K.

• Qian Yi

  Amgen Inc.

• Kajinami Kouji

  Department of Cardiology, Kanazawa Medical University

Abstract

Background:This study examined treatment patterns, possible statin intolerance, and incidence of cardiovascular events (CVEs) in 2 cohorts of patients with high cardiovascular risk (i.e., patients with atherosclerotic cardiovascular disease [ASCVD] and patients with diabetes mellitus). Methods and Results:A retrospective cohort study examined adults initiating either a statin or ezetimibe from 1 January 2006 to 31 May 2014 in the Japan Medical Data Center database. The first observed statin or ezetimibe prescription defined the index date. Patients had ≥12 months of pre- and post-index date plan enrollment. Two high-risk cohorts, the ASCVD cohort and diabetes cohort, were created based on diagnoses observed during the 12 months’ pre-index date. Treatment patterns, possible statin intolerance, and incidence of CVEs were reported. In the ASCVD cohort (n=5,302), 32.9% discontinued therapy, 7.7% switched to a non-index statin or non-statin lipid-lowering therapy, and 11.2% augmented index therapy in the 12 months’ post-index date; only 0.3% were using high-intensity statins and 10% had possible statin intolerance. Also, 8.1% had any new CVE during the follow-up period. Treatment patterns and incidence of CVEs among the diabetes cohort were similar to those of the ASCVD cohort. Conclusions:High cardiovascular risk Japanese patients had frequent treatment modifications, although use of high-intensity statin doses was rare. These patterns may indicate that alternative therapies for lipid lowering are needed.

Journal

• Circulation Journal

  Circulation Journal 82 (4), 1008-1016, 2018

  The Japanese Circulation Society

Keywords

• Atherosclerotic cardiovascular disease
• Cardiovascular event
• Statins
• Treatment patterns

Details

• CRID: 1390282680085661312
• NII Article ID: 130006528547
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-17-0811
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 028895126
• PubMed: 29276211
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028895126
• Web Site: https://www.jstage.jst.go.jp/article/circj/82/4/82_CJ-17-0811/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018289421
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed