The Inhibitory Effect of a Polyphenol Concentrate from Pomegranate Juice on 2,4-dinitrofluorobenzene-induced Contact Hypersensitivity in Mice

DOI Web Site 被引用文献2件
  • Nagano Takao
    Department of Food Science, Faculty of Bioresources and Environmental Sciences, Ishikawa Prefectural University Department of Clinical Nutrition, Faculty of Health Science and Technology, Kawasaki University of Medical Welfare
  • Nishida Norihisa
    Morishita Jintan Co., Ltd.
  • Ito Hideyuki
    Department of Nutritional Science, Faculty of Health and Welfare, Okayama Prefectural University

抄録

<p>Pomegranate juice (PJ) has higher polyphenol content and antioxidative activity than any other fruit juice. We used a pomegranate polyphenol concentrate (PPC) from pomegranate juice and investigated its inhibitory effects and mechanism of action using a contact hypersensitivity (CHS) test. The ear swelling induced by 2,4-dinitrofluorobenzene (DNFB) was inhibited in the PPC-treated group compared to that in the control group. Antigen-specific IgG1 was lower in the PPC-treated group than in the control group; however, serum antigen-specific IgG2a was not different. More splenic IL-10-producing and IFN-γ-/IL-4-producing CD4+ T cells were observed in the PPC-treated group than in the control group. These results suggested that PPC afforded protection against CHS and IgG1 production by increasing IL-10-producing CD4+ T cell numbers.</p>

収録刊行物

被引用文献 (2)*注記

もっと見る

関連プロジェクト

もっと見る

キーワード

詳細情報 詳細情報について

問題の指摘

ページトップへ