Dynamic OCSAを用いた変性軟骨(OA)の力学診断法の総合的検証

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  • Comprehensive verification on Mechanical Diagnosis of Osteoarthritic Cartilage using Dynamic Optical Coherence Straingraphy

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<p>Many of the elderly are predisposed to develop osteoarthritis (OA), although it is quite difficult to diagnose the early-grade OA even by latest imaging modalities. In this study, we have proposed Dynamic Mechanical Analyzing Optical Coherence Straingraphy, namely DMA-OCSA, which is a tomographically micro-visualizing method of visco-elastic properties estimated from continuous OCT images. This is based on the speckle tracking algorithm having high sensitivity and S/N under micrometer resolution, thus can provide temporal and spatial distribution of not only deformation velocity but also strain rate during a dynamic visco-elasticity test. This was experimentally applied to comparatively Osteoarthritic cartilage of animal models. Consequently, the sinusoidal time-varying strain rate was locally observed to have phase difference between the superficial tangential zone and middle zone, which could cause degradation of visco-elasticity.</p>

収録刊行物

  • 年次大会

    年次大会 2017 (0), J0210105-, 2017

    一般社団法人 日本機械学会

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