Administration of Kampo medicine through a tube at an advanced critical care center
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- Niimura Takahiro
- Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School
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- Zamami Yoshito
- Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School Department of Pharmacy, Tokushima University Hospital Department of Emergency Pharmaceutics, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
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- Imai Toru
- Department of Pharmacy, Nihon University Itabashi Hospital
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- Ito Tsuyoshi
- Department of Emergency Pharmaceutics, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
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- Sagara Hidenori
- Department of Pharmaceutical Information Sciences, Matsuyama University
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- Hiroyuki Hichiya
- Godai Pharmacy
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- Esumi Satoru
- Department of Hospital Pharmacy, Okayama University Hospital
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- Takechi Kenshi
- Clinical Trial Center for Developmental Therapeutics, Tokushima University Hospital
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- Imanishi Masaki
- Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School Department of Pharmacy, Tokushima University Hospital
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- Koyama Toshihiro
- Department of Clinical Pharmacy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University
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- Amano Manabu
- Section of Clinical Pharmaceutics, School of Pharmacy, Hyogo University of Health Sciences
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- Kurata Naomi
- School of Pharmacy, Showa University
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- Kitamura Yoshihisa
- Department of Hospital Pharmacy, Okayama University Hospital
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- Nakura Hironori
- Department of Emergency Pharmaceutics, Graduate School of Medicine Dentistry and Pharmaceutical Sciences, Okayama University
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- Sendo Toshiaki
- Department of Hospital Pharmacy, Okayama University Hospital
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- Ishizawa Keisuke
- Department of Clinical Pharmacology and Therapeutics, Institute of Biomedical Sciences, Tokushima University Graduate School Department of Pharmacy, Tokushima University Hospital
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<p>n emergency and critical care medical centers, tube administration is employed for patients who have difficulty swallowing oral drugs owing to decreased consciousness or mechanical ventilation. However, tube clogging due to drug injection is a concern. We compared the crushing method with the simple suspension method for the passage of amlodipine, an antihypertensive drug, in combination with rikkunshito, which has been used to treat upper gastrointestinal disorders such as functional dyspepsia and gastroesophageal reflux in emergency and critical care medical centers, to ascertain the effect of Kampo products on the passage of other drugs during tube administration. When the crushing method was employed, poorly water‐soluble solid products were formed, while a uniformly dispersed suspension was obtained using the simple suspension method. In addition, the passage rate of amlodipine through the tube was 64% and 93% in the crushing and simple suspension methods, respectively, thereby indicating that the simple suspension method provided more favorable than the crushing method. The results of this study suggested that the passage rate of amlodipine for patients who received Kampo products concurrently was higher when the simple suspension method was used, and an appropriate drug amount might well be able to administered to patients using this method. J. Med. Invest. 65:32‐36, February, 2018</p>
収録刊行物
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- The Journal of Medical Investigation
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The Journal of Medical Investigation 65 (1.2), 32-36, 2018
国立大学法人 徳島大学医学部
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詳細情報 詳細情報について
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- CRID
- 1390001204247909120
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- NII論文ID
- 130006575600
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- NII書誌ID
- AA11166929
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- ISSN
- 13496867
- 13431420
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- PubMed
- 29593190
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- IRDB
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可
