Measles Virus

DOI Web Site Web Site PubMed 103 References
  • TAHARA Maino
    Department of Virology III, National Institute of Infectious Diseases
  • TAKEDA Makoto
    Department of Virology III, National Institute of Infectious Diseases

Bibliographic Information

Other Title
  • 麻疹ウイルス
  • ハシカウイルス

Search this article

Abstract

Measles virus (MeV) is exceptionally contagious and still a major cause of death in child.However, recently significant progress towards the elimination of measles has been made through increased vaccination coverage of measles-containing vaccines. The hemagglutinin (H) protein of MeV interacts with a cellular receptor, and this interaction is the first step of infection. MeV uses two different receptors, signaling lymphocyte activation molecule (SLAM) and nectin-4 expressed on immune cells and epithelial cells, respectively. The interactions of MeV with these receptors nicely explain the immune suppressive and high contagious properties of MeV. Binding of the H protein to a receptor triggers conformational changes in the fusion (F) protein, inducing fusion between viral and host plasma membranes for entry. The stalk region of the H protein plays a key role in the F protein-triggering. Recent studies of the H protein epitopes have revealed that the receptor binding site of the H protein constitutes a major neutralizing epitope. The interaction with two proteinaceous receptors probably imposes strong functional constraints on this epitope for amino acid changes. This would be a reason why measles vaccines, which are derived from MV strains isolated more than 60 years ago, are still highly effective against all MV strains currently circulating.

Journal

  • Uirusu

    Uirusu 67 (1), 3-16, 2017

    The Japanese Society for Virology

References(103)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top