Effects of surface microtopography of titanium disks on cell proliferation and differentiation of osteoblast-like cells isolated from rat calvariae
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- YOKOSE Satoshi
- Division of Endodontic and Operative Dentistry, Department of Restorative and Biomaterials Sciences, School of Dentistry, Meikai University
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- KLOKKEVOLD Perry R.
- Division of Constitutive and Regenerative Sciences, Section of Periodontics, School of Dentistry University California Los Angels
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- TAKEI Henry H.
- Division of Constitutive and Regenerative Sciences, Section of Periodontics, School of Dentistry University California Los Angels
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- KADOKURA Hiroshi
- Division of Endodontic and Operative Dentistry, Department of Restorative and Biomaterials Sciences, School of Dentistry, Meikai University
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- KIKUI Tetsuya
- Division of Operative Dentistry, Department of Conservative Dentistry, School of Dentistry, Ohu University
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- HIBINO Yasushi
- Division of Dental Materials Science, Department of Restorative and Biomaterials Sciences, School of Dentistry, Meikai University
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- SHIGETA Hirotaka
- Division of Dental Materials Science, Department of Restorative and Biomaterials Sciences, School of Dentistry, Meikai University
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- NAKAJIMA Hiroshi
- Division of Dental Materials Science, Department of Restorative and Biomaterials Sciences, School of Dentistry, Meikai University
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- KAWAZU Hiroshi
- Section of Continuous Education, School of Dentistry, Meikai University
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抄録
<p>The surface topography of implant fixture is an important factor affecting the osseointegration. We herein demonstrated the effects of surface microtopography of titanium disks on proliferation and differentiation of osteoblast-like cells isolated from rat calvariae. Titanium disks with machine surface (MS), rough surface (R1) and rough surface combined with small cavities (R2) were used in an in vitro culture system. Rough surfaces (R1 and R2 disks) induced stronger osteoblast proliferation and differentiation (BGP and sclerostin mRNA expressions and calcium content) than the smooth surface (MS disk). Furthermore, surface microtopography of R2 disk, which was rough with small cavities, more strongly induced cell proliferation and mineralized bone matrix production than R1 disk. Our results suggest that surface microtopography influences osteoblast proliferation and differentiation. R2 disk, which is rough with small cavities, may be used in implant fixtures to increase osseointegration.</p>
収録刊行物
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- Dental Materials Journal
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Dental Materials Journal 37 (2), 272-277, 2018
日本歯科理工学会