Chemical Structures of Novel Maillard Reaction Products under Hyperglycemic Conditions
-
- Imahori Daisuke
- Kyoto Pharmaceutical University
-
- Matsumoto Takahiro
- Kyoto Pharmaceutical University
-
- Kojima Naoto
- Kyoto Pharmaceutical University
-
- Hasei Tomohiro
- Kyoto Pharmaceutical University
-
- Sumii Megumi
- Kyoto Pharmaceutical University
-
- Sumida Taishi
- Kyoto Pharmaceutical University
-
- Yamashita Masayuki
- Kyoto Pharmaceutical University
-
- Watanabe Tetsushi
- Kyoto Pharmaceutical University
Search this article
Abstract
<p>Two novel and two known compounds, 4-quinolylaldoxime and indole-3-aldehyde, were isolated from a reaction mixture consisting of D-glucose and L-tryptophan at physiological temperature and pH. The chemical structures of the two novel compounds were elucidated by spectroscopic analysis such as X-ray crystallography. One of the novel compound and the indole-3-aldehyde showed mutagenicity toward Salmonella typhimurium YG1024 with S9 mix. Furthermore, 4-quinolylaldoxime was detected from streptozotocin-induced diabetic rat plasma by LC-MS/MS analysis; however, the isolated compounds were not detected in rat diet extracts. To our knowledge, this is the first report in which 4-quinolylaldoxime was detected in rat plasma. These results suggest that amino-carbonyl reaction products may be formed in diabetic condition and induce genetic damage.</p>
Journal
-
- Chemical and Pharmaceutical Bulletin
-
Chemical and Pharmaceutical Bulletin 66 (4), 363-367, 2018
The Pharmaceutical Society of Japan
- Tweet
Details 詳細情報について
-
- CRID
- 1390001204178690560
-
- NII Article ID
- 130006602063
-
- NII Book ID
- AA00602100
-
- ISSN
- 13475223
- 00092363
-
- NDL BIB ID
- 028907412
-
- PubMed
- 29607901
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed