Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by <i>ALDH2</i> and <i>ADH1B</i> Polymorphisms in Japanese Men

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Author(s)

    • Sasakabe Tae
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • Hara Megumi
    • Department of Preventive Medicine, Faculty of Medicine, Saga University
    • Kuriyama Nagato
    • Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science
    • Hirata Akie
    • Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University
    • Mikami Haruo
    • Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center Research Institute
    • Oze Isao
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute
    • Tanaka Hideo
    • Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute|Department of Epidemiology, Nagoya University Graduate School of Medicine
    • Hamajima Nobuyuki
    • Department of Healthcare Administration, Nagoya University Graduate School of Medicine
    • Wakai Kenji
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • Kawai Sayo
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • Hishida Asahi
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • Naito Mariko
    • Department of Preventive Medicine, Nagoya University Graduate School of Medicine
    • Suzuki Sadao
    • Department of Public Health, Nagoya City University Graduate School of Medical Sciences
    • Nindita Yora
    • Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences|Department of Pharmacology and Therapeutic, Faculty of Medicine, Diponegoro University
    • Arisawa Kokichi
    • Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School

Abstract

<p><b>Background:</b> Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of <i>ADH1B</i> His48Arg (rs1229984), <i>ALDH2</i> Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for <i>ALDH2</i> could be replicated.</p><p><b>Methods:</b> We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study.</p><p><b>Results:</b> The <i>ALDH2 Glu/Lys</i> or <i>Lys/Lys</i> groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (<i>P</i> for interaction = 0.006). This inverse correlation was more evident among the <i>ADH1B His/His</i> + <i>ALDH2 Glu/Lys</i> or <i>Lys/Lys</i> groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the <i>ADH1B His/His</i> group (<i>P</i> for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the <i>ALDH2 Glu/Lys</i> or <i>Lys/Lys</i> groups was replicated.</p><p><b>Conclusions:</b> The <i>ALDH2</i> Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.</p>

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 28(4), 185-193, 2018

    Japan Epidemiological Association

Codes

  • NII Article ID (NAID)
    130006638863
  • Text Lang
    ENG
  • ISSN
    0917-5040
  • Data Source
    J-STAGE 
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