Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by <i>ALDH2</i> and <i>ADH1B</i> Polymorphisms in Japanese Men

• Sasakabe Tae

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Wakai Kenji

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Kawai Sayo

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Hishida Asahi

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Naito Mariko

  Department of Preventive Medicine, Nagoya University Graduate School of Medicine

• Suzuki Sadao

  Department of Public Health, Nagoya City University Graduate School of Medical Sciences

• Nindita Yora

  Department of International Island and Community Medicine, Kagoshima University Graduate School of Medical and Dental Sciences Department of Pharmacology and Therapeutic, Faculty of Medicine, Diponegoro University

• Arisawa Kokichi

  Department of Preventive Medicine, Institute of Biomedical Sciences, Tokushima University Graduate School

• Kita Yoshikuni

  Faculty of Nursing Science, Tsuruga Nursing University

• Hara Megumi

  Department of Preventive Medicine, Faculty of Medicine, Saga University

• Kuriyama Nagato

  Department of Epidemiology for Community Health and Medicine, Kyoto Prefectural University of Medicine Graduate School of Medical Science

• Hirata Akie

  Department of Geriatric Medicine, Graduate School of Medical Sciences, Kyushu University

• Mikami Haruo

  Division of Cancer Registry, Prevention and Epidemiology, Chiba Cancer Center Research Institute

• Oze Isao

  Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute

• Kubo Michiaki

  Center for Integrative Medical Sciences, RIKEN

• Tanaka Hideo

  Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute Department of Epidemiology, Nagoya University Graduate School of Medicine

• Hamajima Nobuyuki

  Department of Healthcare Administration, Nagoya University Graduate School of Medicine

Bibliographic Information

Other Title

• Modification of the Associations of Alcohol Intake With Serum Low-Density Lipoprotein Cholesterol and Triglycerides by ALDH2 and ADH1B Polymorphisms in Japanese Men

Abstract

Background: Although beneficial associations have been reported between moderate alcohol intake and the serum lipid profile, it is unclear whether polymorphisms in alcohol-metabolizing enzymes can modify these associations. Here, we assessed the effects of ADH1B His48Arg (rs1229984), ALDH2 Glu504Lys (rs671), and their combination on these associations. Furthermore, we examined if the findings for ALDH2 could be replicated. Methods: We categorized 889 male participants in the Japan Multi-Institutional Collaborative Cohort (J-MICC) Study into two groups based on presence or absence of minor allele(s) or four groups based on genotype combinations. We performed regression analyses of serum lipid concentrations on alcohol intake, with multivariable adjustment. The replication study was conducted among 2,562 men in the Shizuoka part of the J-MICC Study. Results: The ALDH2 Glu/Lys or Lys/Lys groups showed significant decreases in serum low-density lipoprotein (LDL) cholesterol with increasing alcohol consumption; the coefficient per intake increase of 10 g/day was −2.49 mg/dL (95% confidence interval [CI], −3.85 to −1.13), and a significant interaction with the polymorphism was confirmed (P for interaction = 0.006). This inverse correlation was more evident among the ADH1B His/His + ALDH2 Glu/Lys or Lys/Lys groups (−3.24 mg/dL, 95% CI, −5.03 to −1.45). Serum triglycerides were positively associated with alcohol consumption in the ADH1B His/His group (P for interaction = 0.020). The stronger association between serum LDL cholesterol and alcohol consumption in the ALDH2 Glu/Lys or Lys/Lys groups was replicated. Conclusions: The ALDH2 Glu504Lys polymorphism can modify the association between alcohol intake and serum LDL cholesterol in Japanese men.

Journal

• Journal of Epidemiology

  Journal of Epidemiology 28 (4), 185-193, 2018

  Japan Epidemiological Association

Keywords

• <i>ALDH2</i>
• <i>ADH1B</i>
• alcohol intake
• lipid profile

Details

• CRID: 1390282679451090176
• NII Article ID: 120006939616
• NII Article ID: 130006638863
• NII Book ID: AA10952696
• DOI: 10.2188/jea.je20160189
• ISSN: 13499092
• ISSN: 09175040
• PubMed: 29176272
• Web Site: http://repo.lib.tokushima-u.ac.jp/114554
• Web Site: https://www.jstage.jst.go.jp/article/jea/28/4/28_JE20160189/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019042919
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed