<b>Circadian rhythms of micturition during jet </b><b>lag </b>

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Author(s)

    • ITO Kakeru
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • DOI Masao
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • OKAMURA Hitoshi
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • YASUDA Miho
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • MAEDA Yuki
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • FUSTIN Jean-Michel
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • YAMAGUCHI Yoshiaki
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • KONO Yuka
    • Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University
    • OGAWA Osamu
    • Department of Urology, Graduate School of Medicine, Kyoto University

Abstract

<p>Micturition behavior follows regular day/night fluctuations, and unwanted increase in micturition could occur during night in jet lag condition. To clarify the effect of jet lag on micturition behavior, we simultaneously detected circadian micturition patterns and locomotor activity rhythms of mice under experimental jet lag conditions, by applying the improved automated Voided Stain on Paper (aVSOP) method. When wild-type (WT) mice were phase-advanced for 8 hours, day-night variation of micturition was disrupted suddenly, and this irregular daily micturition continued until 8 days, although their activity rhythms entrained gradually day by day until 8 days. We also examined how jet lag induced changes of micturition in <i>Per</i>-null mice lacking <i>Per1</i>, <i>Per2</i> and <i>Per3</i> genes, whose endogenous clock is completely disrupted. We found both micturition and locomotor activity of <i>Per</i>-null mice promptly entrained to the new LD cycle. These findings suggest that the irregular micturition during jet lag is caused along with the gradual shift of the endogenous clock, and paradoxically, jet lag-associated abnormality was absent when endogenous circadian oscillations were genetically disrupted.</p>

Journal

  • Biomedical Research

    Biomedical Research 39(2), 57-63, 2018

    Biomedical Research Press

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