Detection of Acetaldehyde in the Esophageal Tissue among Healthy Male Subjects after Ethanol Drinking and Subsequent L-Cysteine Intake

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Author(s)

    • Okata Hideki
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Masamune Atsushi
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Shimosegawa Tooru
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Hatta Waku
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Iijima Katsunori
    • Department of Gastroenterology and Neurology, Akita University Graduate School of Medicine
    • Asanuma Kiyotaka
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Tsuruya Atsuki
    • Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University
    • Asano Naoki
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Koike Tomoyuki
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Hamada Shin
    • Division of Gastroenterology, Tohoku University Graduate School of Medicine
    • Nakayama Toru
    • Department of Biomolecular Engineering, Graduate School of Engineering, Tohoku University

Abstract

<p>Ethanol is oxidized by alcohol dehydrogenase to acetaldehyde, a recognized carcinogen for the esophagus. However, no previous study has measured the acetaldehyde levels in the esophageal tissue. L-cysteine has been shown to reduce the acetaldehyde levels in the saliva; however, it is unknown whether L-cysteine intake affects the acetaldehyde concentration in the esophageal tissue. The aim of this study was to measure the acetaldehyde concentration in the esophageal tissue after ethanol drinking and evaluate the effect of L-cysteine intake on the acetaldehyde levels in the esophagus. We enrolled 10 male subjects with active <i>acetaldehyde dehydrogenase-2*1/*1 </i>(<i>ALDH2*1/*1</i>) genotype and 10 male subjects with the inactive<i> acetaldehyde dehydrogenase-2*1/*2 </i>(<i>ALDH2*1/*2</i>) genotype, the mean ages of whom were 25.6 and 27.9 years, respectively. In this prospective, single-blind, placebo-controlled study using L-cysteine and placebo lozenges (first and second examination), saliva and blood were collected before and after ethanol drinking. Esophageal tissue was obtained by endoscopic biopsy at 60 minutes after drinking, and the acetaldehyde and ethanol concentrations were measured. The acetaldehyde concentration of the saliva was significantly lower in those taking L-cysteine than in those taking the placebo. Acetaldehyde in the esophageal tissue was detected only in those taking L-cysteine lozenges. There were no correlations between the acetaldehyde concentrations in the esophageal tissue and saliva or blood. In conclusion, we detected acetaldehyde in the human esophageal tissue after ethanol drinking. Unexpectedly, intake of L-cysteine lozenges appears to contribute to detection of acetaldehyde in the esophageal tissue.</p>

Journal

  • The Tohoku Journal of Experimental Medicine

    The Tohoku Journal of Experimental Medicine 244(4), 317-325, 2018

    Tohoku University Medical Press

Codes

  • NII Article ID (NAID)
    130006712062
  • Text Lang
    ENG
  • ISSN
    0040-8727
  • Data Source
    J-STAGE 
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