Up-regulation of serum periostin and squamous cell carcinoma antigen levels in infants with acute bronchitis due to respiratory syncytial virus
-
- Nakamura Hiroaki
- Department of Pediatrics, Toho University Ohashi Medical Center Department of Pediatrics, The Jikei University School of Medicine
-
- Akashi Kenichi
- Department of Pediatrics, The Jikei University School of Medicine
-
- Watanabe Masako
- Department of Pediatrics, The Jikei University School of Medicine
-
- Ohta Shoichiro
- Department of Laboratory Medicine, Saga Medical School
-
- Ono Junya
- Shino-Test Corporation
-
- Azuma Yoshinori
- Shino-Test Corporation
-
- Ogasawara Noriko
- Department of Microbiology, Sapporo Medical University School of Medicine
-
- Yamamoto Keisuke
- Department of Otorhinolaryngology, Sapporo Medical University School of Medicine
-
- Shimizu Norikazu
- Department of Pediatrics, Toho University Ohashi Medical Center
-
- Tsutsumi Hiroyuki
- Department of Pediatrics, Sapporo Medical University School of Medicine
-
- Izuhara Kenji
- Division of Medical Biochemistry, Department of Biomolecular Sciences, Saga Medical School
-
- Katsunuma Toshio
- Department of Pediatrics, The Jikei University School of Medicine
この論文をさがす
抄録
<p>Background: Periostin and squamous cell carcinoma antigen (SCCA) are involved in the pathogenesis of asthma. Acute bronchitis due to respiratory syncytial virus (RSV) infection during infancy exhibits an asthma-like pathogenesis, suggesting that it may be associated with the subsequent development of asthma. However, the mechanism by which RSV infection leads to development of asthma has not yet been fully elucidated.</p><p>Methods: Infants younger than 36 months were enrolled and classified into three groups. Group I included patients hospitalized with RSV-induced bronchitis. These patients were further stratified into two sub-groups according to whether the criteria for the modified Asthma Predictive Index (mAPI) had been met: Group I consisted of mAPI (+) and mAPI (-) patients; Group II included patients with food allergy as a positive control group; and Group III included children with no allergy as a negative control group. Serum periostin and SCCA levels were measured in the groups. This study was registered as a clinical trial (UMIN000012339).</p><p>Results: We enrolled 14 subjects in Group I mAPI (+), 22 in Group I mAPI (-), 18 in Group II, and 18 in Group III. In Group I, the serum periostin and SCCA levels were significantly higher during the acute phase compared with the recovery phase. However, no significant differences were found between Group I mAPI (+) and mAPI (-).</p><p>Conclusions: The serum periostin and SCCA levels increased during acute RSV bronchitis. Both periostin and SCCA may play a role in the pathogenesis of acute bronchitis due to RSV.</p>
収録刊行物
-
- Allergology International
-
Allergology International 67 (2), 259-265, 2018
一般社団法人日本アレルギー学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390282679611248768
-
- NII論文ID
- 130006721831
-
- ISSN
- 14401592
- 13238930
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- Crossref
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可