Chronic spontaneous urticaria and the extrinsic coagulation system
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- Yanase Yuhki
- Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University
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- Takahagi Shunsuke
- Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University
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- Hide Michihiro
- Department of Dermatology, Institute of Biomedical & Health Sciences, Hiroshima University
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<p>Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by daily or almost daily recurring skin edema and flare with itch. Recently, the activation of the blood coagulation cascade has been suggested to be involved in CSU, but the trigger of the coagulation cascade remains unclear. In this article, we review recent understanding of the relationship between the pathogenesis of CSU and extrinsic coagulation reactions. In CSU, vascular endothelial cells and eosinophils may play a role as TF-expressing cells for activating the extrinsic coagulation pathway. Moreover, the expression of TF on endothelial cells is synergistically enhanced by the activation of Toll-like receptors and histamine H1 receptors. The activated coagulation factors may induce plasma extravasation followed by degranulation of skin mast cells and edema formation recognized as wheal in CSU. Molecules involved in this cascade could be a target for new and more effective treatments of urticaria.</p>
収録刊行物
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- Allergology International
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Allergology International 67 (2), 191-194, 2018
一般社団法人日本アレルギー学会
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詳細情報 詳細情報について
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- CRID
- 1390001204634539136
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- NII論文ID
- 130006721833
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- ISSN
- 14401592
- 13238930
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- CiNii Articles
- KAKEN
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- 使用不可