Effect of Daily Light on c-Fos Expression in the Suprachiasmatic Nucleus under Jet Lag Conditions

• Chen Yulin

  Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Yamaguchi Yoshiaki

  Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Suzuki Toru

  Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University Present address: Department of Neuroscience II, Research Institute of Environmental Medicine (RIEM), Nagoya University

• Doi Masao

  Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University

• Okamura Hitoshi

  Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University

Abstract

Jet-lag symptoms arise from temporal misalignment between the internal circadian clock and external solar time when traveling across multiple time zones. Light is known as a strong timing cue of the circadian clock. We here examined the effect of daily light on the process of jet lag by detecting c-Fos expression in the master clock neurons in the suprachiasmatic nucleus (SCN) under 8-hr phase-advanced jet lag condition. In WT mice, c-Fos-immunoreactivity was found at 1–2 hours on the first day after light/dark (LD) phase-advance. This induction was also observed on the second and third days, although their levels were diminished day by day. In contrast, c-Fos induction in the SCN of V1a^–/–V1b^–/– mice, which show virtually no jet lag symptoms even after 8-hr phase-advance, was only detected on the first day. These results indicate that external light has affected SCN neuronal activity for 3 days after LD phase-advance in WT mice suggesting the continuous progress of activity change of SCN neurons under jet lag conditions. Noteworthy, limited c-Fos induction in V1a^–/–V1b^–/– SCN is also consistent with the rapid reentrainment of the SCN clock in mutant mice after 8-hr LD phase-advance.

Journal

• ACTA HISTOCHEMICA ET CYTOCHEMICA

  ACTA HISTOCHEMICA ET CYTOCHEMICA 51 (2), 73-80, 2018

  JAPAN SOCIETY OF HISTOCHEMISTRY AND CYTOCHEMISTRY

Keywords

• circadian rhythm
• suprachiasmatic nucleus
• c-Fos
• jet lag
• vasopressin receptor

Details

• CRID: 1390282679838201856
• NII Article ID: 130006727962
• DOI: 10.1267/ahc.18001
• ISSN: 13475800
• ISSN: 00445991
• Web Site: https://www.jstage.jst.go.jp/article/ahc/51/2/51_18001/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019171036
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed