Gender Difference and Dietary Supplemental Vitamin B₆ : Impact on Colon Luminal Environment
-
- NIRMAGUSTINA Dwi Eva
- Graduate School of Biosphere Science, Hiroshima University
-
- YANG Yongshou
- Graduate School of Biosphere Science, Hiroshima University
-
- KUMRUNGSEE Thanutchaporn
- Graduate School of Biosphere Science, Hiroshima University
-
- YANAKA Noriyuki
- Graduate School of Biosphere Science, Hiroshima University
-
- KATO Norihisa
- Graduate School of Biosphere Science, Hiroshima University
書誌事項
- タイトル別名
-
- Gender Difference and Dietary Supplemental Vitamin B<sub>6</sub>: Impact on Colon Luminal Environment
この論文をさがす
抄録
Colon diseases can be affected by several factors such as gender difference and dietary supplemental vitamin B6 (B6). The nutritional status of B6 is affected by gender difference, leading us to hypothesize that gender difference affects colon luminal environment, which is dependent on B6 status. To investigate this hypothesis, we fed male and female rats a diet containing 1 mg, 7 mg, or 35 mg pyridoxine HCl/kg diet for 6 wk. We found significantly higher fecal mucin levels in female rats compared to those in male rats. Supplemental B6 significantly increased fecal mucins and was particularly profound in the female rats. The abundances of cecal and fecal Akkermansia muciniphila (mucin degrader) were unaffected. The fecal mucin levels were significantly correlated with colonic free threonine and serine and with gene expression of colon MUC16, implying that the combined effect of gender and dietary B6 on fecal mucins was mediated by the alteration in the levels of such amino acids and MUC16 expression. This study further showed the significant effects of gender difference on colonic free amino acids such as threonine, ornithine, asparagine/aspartate ratio, and glutamine/glutamate ratio, cecal and fecal Lactobacillus spp. levels, and colonic gene expressions of MUC16 and TLR8, the factors relating to colon health and diseases. Therefore, our findings suggest that gender difference and dietary B6 may have an impact on colon diseases by modulating these parameters.
収録刊行物
-
- Journal of Nutritional Science and Vitaminology
-
Journal of Nutritional Science and Vitaminology 64 (2), 116-128, 2018
一般財団法人 学会誌刊行センター
- Tweet
詳細情報 詳細情報について
-
- CRID
- 1390282681301733120
-
- NII論文ID
- 130006728835
-
- NII書誌ID
- AA00703822
-
- ISSN
- 18817742
- 03014800
-
- NDL書誌ID
- 028958890
-
- PubMed
- 29710029
-
- 本文言語コード
- en
-
- データソース種別
-
- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可