Viral and Electrophysiological Approaches for Elucidating the Structure and Function of Retinal Circuits

• Onda Masanari

  Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University

• Sansawa Kouki

  Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University

• Osakada Fumitaka

  Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University Systems Neurobiology Laboratory, The Salk Institute for Biological Studies PRESTO, Japan Science and Technology Agency

Bibliographic Information

Other Title

• 網膜神経回路を解析するウイルス遺伝子工学と電気生理学的手法
• Symposium Review 網膜神経回路を解析するウイルス遺伝子工学と電気生理学的手法
• Symposium Review モウマク シンケイ カイロ オ カイセキ スル ウイルス イデンシ コウガク ト デンキ セイリガクテキ シュホウ

Abstract

　The mammalian retina consists of five classes of neurons: photoreceptor, horizontal, bipolar, amacrine, and ganglion cells. Based on cell morphology, electrophysiological properties, connectivity, and gene expression patterns, each class of retinal neurons is further subdivided into many distinct cell types. Each type of photoreceptor, bipolar, and ganglion cell tiles the retina, collectively providing a complete representation across the visual scene. Visual signals are processed by at least 80 distinct cell types and at least 20 separate circuits in the retina. These circuits comprise parallel pathways from the photoreceptor cells to ganglion cells, each forming a channel of visual information. Feed-forward and feedback inhibition of horizontal and amacrine cells shape these parallel pathways. However, the cell-type-specific roles of inhibitory circuits in retinal information processing remain unknown. Here we summarize parallel processing strategies in the retina, and then introduce our viral and electrophysiological approaches that reveal the roles of genetically defined subtypes of amacrine cells in retinal circuits.<br>

Journal

• YAKUGAKU ZASSHI

  YAKUGAKU ZASSHI 138 (5), 669-678, 2018-05-01

  The Pharmaceutical Society of Japan

Keywords

• inhibitory neuron
• visual processing
• neural circuit
• cell type
• parallel pathway

Details

• CRID: 1390001206215702016
• NII Article ID: 130006729442
• NII Book ID: AN00284903
• DOI: 10.1248/yakushi.17-00200-1
• ISSN: 13475231
• ISSN: 00316903
• NDL BIB ID: 029035527
• PubMed: 29710012
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029035527
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/138/5/138_17-00200-1/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed