網膜神経回路を解析するウイルス遺伝子工学と電気生理学的手法  [in Japanese] Viral and Electrophysiological Approaches for Elucidating the Structure and Function of Retinal Circuits  [in Japanese]

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Author(s)

    • 恩田 将成 Onda Masanari
    • 名古屋大学大学院創薬科学研究科細胞薬効解析学分野 Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University
    • 三澤 幸樹 Sansawa Kouki
    • 名古屋大学大学院創薬科学研究科細胞薬効解析学分野 Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University
    • 小坂田 文隆 Osakada Fumitaka
    • 名古屋大学大学院創薬科学研究科細胞薬効解析学分野|名古屋大学高等研究院神経情報処理研究チーム|ソーク研究所システムズニューロバイオロジー研究グループ|科学技術振興機構さきがけ Laboratory of Cellular Pharmacology, Graduate School of Pharmaceutical Sciences, Nagoya University|Laboratory of Neural Information Processing, Institute for Advanced Research, Nagoya University|Systems Neurobiology Laboratory, The Salk Institute for Biological Studies|PRESTO, Japan Science and Technology Agency

Abstract

 The mammalian retina consists of five classes of neurons: photoreceptor, horizontal, bipolar, amacrine, and ganglion cells. Based on cell morphology, electrophysiological properties, connectivity, and gene expression patterns, each class of retinal neurons is further subdivided into many distinct cell types. Each type of photoreceptor, bipolar, and ganglion cell tiles the retina, collectively providing a complete representation across the visual scene. Visual signals are processed by at least 80 distinct cell types and at least 20 separate circuits in the retina. These circuits comprise parallel pathways from the photoreceptor cells to ganglion cells, each forming a channel of visual information. Feed-forward and feedback inhibition of horizontal and amacrine cells shape these parallel pathways. However, the cell-type-specific roles of inhibitory circuits in retinal information processing remain unknown. Here we summarize parallel processing strategies in the retina, and then introduce our viral and electrophysiological approaches that reveal the roles of genetically defined subtypes of amacrine cells in retinal circuits.<br>

Journal

  • YAKUGAKU ZASSHI

    YAKUGAKU ZASSHI 138(5), 669-678, 2018

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130006729442
  • NII NACSIS-CAT ID (NCID)
    AN00284903
  • Text Lang
    JPN
  • ISSN
    0031-6903
  • NDL Article ID
    029035527
  • NDL Call No.
    Z19-411
  • Data Source
    NDL  J-STAGE 
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