Highlighted Paper selected by Editor-in-Chief : Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives

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  • Kobayashi Hiroyuki
    Division of Organic Chemistry, National Institute of Health Sciences Department of Chemistry and Life Science, Kogakuin University
  • Misawa Takashi
    Division of Organic Chemistry, National Institute of Health Sciences
  • Oba Makoto
    Graduate School of Biomedical Sciences, Nagasaki University
  • Hirata Naoya
    Division of Pharmacology, National Institute of Health Sciences
  • Kanda Yasunari
    Division of Pharmacology, National Institute of Health Sciences
  • Tanaka Masakazu
    Graduate School of Biomedical Sciences, Nagasaki University
  • Matsuno Kenji
    Department of Chemistry and Life Science, Kogakuin University
  • Demizu Yosuke
    Division of Organic Chemistry, National Institute of Health Sciences

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  • Structural Development of Cell-Penetrating Peptides Containing Cationic Proline Derivatives

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<p>We designed and synthesized a series of cell-penetrating peptides containing cationic proline derivatives (ProGu) that exhibited responsive changes in their secondary structures to the cellular environment. Effects of the peptide length and steric arrangement of the side chain in cationic proline derivatives [Pro4SGu and Pro4RGu] on their secondary structures and cell membrane permeability were investigated. Moreover, peptides 3 and 8 exhibited efficient intracellular delivery of plasmid DNA.</p>

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