A High-Fat and High-Cholesterol Diet Induces Cardiac Fibrosis, Vascular Endothelial, and Left Ventricular Diastolic Dysfunction in SHRSP5/Dmcr Rats

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Author(s)

    • Watanabe Shogo
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University
    • Kusachi Shozo
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University
    • Mori Mari
    • Institute for World Health Development, Mukogawa Women's University
    • Yamori Yukio
    • Institute for World Health Development, Mukogawa Women's University
    • Oka Hisao
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University
    • Kumazaki Shota
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University
    • Kusunoki Katsuhiro
    • Department of Medical Technology, Faculty of Health Sciences, Okayama University
    • Inoue Terumi
    • Department of Medical Technology, Faculty of Health Sciences, Okayama University
    • Maeda Yui
    • Department of Medical Technology, Faculty of Health Sciences, Okayama University
    • Usui Shinichi
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University
    • Shinohata Ryoko
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University
    • Ohtsuki Takashi
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University
    • Hirohata Satoshi
    • Department of Medical Technology, Graduate School of Health Sciences, Okayama University

Abstract

<p><b><i>Aim</i></b>: Non-alcoholic steatohepatitis (NASH) increases cardiovascular risk regardless of risk factors in metabolic syndrome. However, the intermediary factors between NASH and vascular disease are still unknown because a suitable animal model has never been established. The stroke-prone (SP) spontaneously hypertensive rat, SHRSP5/Dmcr, simultaneously develops hypertension, acute arterial lipid deposits in mesenteric arteries, and NASH when feed with a high-fat and high-cholesterol (HFC) diet. We investigated whether SHRSP5/Dmcr affected with NASH aggravates the cardiac or vascular dysfunction.</p><p><b><i>Method</i></b>: Wister Kyoto and SHRSP5/Dmcr rats were divided into 4 groups of 5 rats each, and fed with a SP or HFC diet. After 8 weeks of HFC or SP diet feeding, glucose and insulin resistance, echocardiography, blood biochemistry, histopathological staining, and endothelial function in aorta were evaluated.</p><p><b><i>Results</i></b>: We demonstrate that SHRSP5/Dmcr rats fed with a HFC diet presented with cardiac and vascular dysfunction caused by cardiac fibrosis, endothelial dysfunction, and left ventricular diastolic dysfunction, in association with NASH and hypertension. These cardiac and vascular dysfunctions were aggravated and not associated with the presence of hypertension, glucose metabolism disorder, and/or obesity.</p><p><b><i>Conclusions</i></b>: SHRSP5/Dmcr rats may be a suitable animal model for elucidating the organ interaction between NASH and cardiac or vascular dysfunction.</p>

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 25(5), 439-453, 2018

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130006729837
  • Text Lang
    ENG
  • ISSN
    1340-3478
  • Data Source
    J-STAGE 
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