Newly-Developed Positron Emission Mammography (PEM) Device for the Detection of Small Breast Cancer

• Yanai Ai

  Department of Surgical Oncology, Tohoku University Graduate School of Medicine Department of Pharmacology, Tohoku University Graduate School of Medicine

• Itoh Masatoshi

  Sendai Medical Imaging Center Cyclotron Radioisotope Center (CYRIC), Tohoku University

• Hirakawa Hisashi

  KKR Tohoku Kosai Hospital

• Yanai Kazuhiko

  Cyclotron Radioisotope Center (CYRIC), Tohoku University Department of Pharmacology, Tohoku University Graduate School of Medicine

• Tashiro Manabu

  Cyclotron Radioisotope Center (CYRIC), Tohoku University

• Harada Ryuichi

  Department of Pharmacology, Tohoku University Graduate School of Medicine

• Yoshikawa Akira

  Institute for Material Research, Tohoku University

• Yamamoto Seiichi

  Department of Radiological Technology, Nagoya University

• Ohuchi Noriaki

  Department of Surgical Oncology, Tohoku University Graduate School of Medicine

• Ishida Takanori

  Department of Surgical Oncology, Tohoku University Graduate School of Medicine

Abstract

Positron emission mammography (PEM) has higher detection sensitivity for breast cancer compared with whole-body positron emission tomography (PET) due to higher spatial resolution. We have developed a new PEM device with high resolution over a wide field of view. This PEM device comprises novel scintillation crystals, praseodymium-doped lutetium aluminum garnet (Pr:LuAG). In the present study, the clinical use of the newly developed PEM for the detection of small breast cancer was compared with that of the conventional PET-computed tomography (PET/CT). Eighty-two patients with breast cancer less than 20 mm (UICC T1) participated in this study, including 23 patients with T1a or T1b breast cancer (less than 10 mm). Histologically-proved lesions were examined by PET/CT and PEM on the same day after injection of [¹⁸F]fluoro-2-deoxy-2-fluoro-D-glucose ([¹⁸F]FDG), a marker of glycolytic activity. The newly developed PEM showed better sensitivity of cancer detection compared with PET/CT especially in case of the small T1a or T1b lesions. Moreover, when the conventional PET/CT and new PEM were combined, the detection sensitivity with [¹⁸F]FDG molecular imaging for T1 (N = 82) and T1a plus T1b breast cancer (N = 23) were 90% and 70%, respectively. The uptake of [¹⁸F]FDG was proportional to the histological malignancy of breast cancer. Using the newly-developed PEM with [¹⁸F]FDG, we are able to identify and characterize exactly the small breast tumors less than 10 mm in combination with the conventional PET/CT. These data indicate that PEM and PET/CT are synergic and complementary for the detection of small breast cancer.

Journal

• The Tohoku Journal of Experimental Medicine

  The Tohoku Journal of Experimental Medicine 245 (1), 13-19, 2018

  Tohoku University Medical Press

Keywords

• breast cancer
• ¹⁸F-FDG
• histology
• PET/CT
• positron emission mammography (PEM)

Details

• CRID: 1390282679220620928
• NII Article ID: 130006731329
• DOI: 10.1620/tjem.245.13
• ISSN: 13493329
• ISSN: 00408727
• PubMed: 29731479
• Web Site: https://www.jstage.jst.go.jp/article/tjem/245/1/245_13/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019202635
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed