Long-term Impact of Cardiorespiratory Fitness on Type 2 Diabetes Incidence: A Cohort Study of Japanese Men

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Author(s)

    • Miyachi Motohiko
    • Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition
    • Sawada Susumu S.
    • Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition
    • Lee I-Min
    • Division of Preventive Medicine, Brigham and Women's Hospital, Harvard Medical School|Department of Epidemiology, Harvard T.H. Chan School of Public Health
    • Gando Yuko
    • Department of Health Promotion and Exercise, National Institutes of Biomedical Innovation, Health and Nutrition
    • Momma Haruki
    • Division of Biomedical Engineering for Health and Welfare, Tohoku University Graduate School of Biomedical Engineering
    • Terada Shin
    • Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo

Abstract

<p><b>Background:</b> We sought to examine the association between cardiorespiratory fitness (CRF) and incidence of type 2 diabetes considering the follow-up period in a cohort of Japanese men with a maximum follow-up period of 23 years.</p><p><b>Methods:</b> This study enrolled 7,804 male workers free of diabetes in 1986. CRF was measured using a cycle ergometer, and maximal oxygen uptake was estimated. During 1986–2009, participants were followed for development of type 2 diabetes, which was diagnosed using fasting blood tests, self-administered questionnaires, or oral glucose tolerance tests after urinary tests from annual health checkups. Hazard ratios for the incidence of type 2 diabetes were estimated using Cox proportional hazards models.</p><p><b>Results:</b> During the follow-up period, 1,047 men developed type 2 diabetes. In analyses by follow-up periods (1986–1993, 1994–2001, and 2002–2009), there was an inverse dose-response relationship between CRF and the development of type 2 diabetes for all three follow-up periods (<i>P</i> for trend 0.019, <0.001, and 0.001, respectively), and the association between CRF at baseline and the incidence of type 2 diabetes did not weaken with longer follow-up period. Compared with the lowest CRF group, hazard ratios of developing type 2 diabetes were 0.69 (95% confidence interval [CI], 0.49–0.97) for the highest CRF group in 1986–1993, 0.57 (95% CI, 0.42–0.79) for the highest CRF in 1994–2001, and 0.47 (95% CI, 0.30–0.74) for the highest CRF in 2002–2009.</p><p><b>Conclusion:</b> High CRF is associated with a lower risk of the incidence of type 2 diabetes over an extended period of >20 years among men.</p>

Journal

  • Journal of Epidemiology

    Journal of Epidemiology 28(5), 266-273, 2018

    Japan Epidemiological Association

Codes

  • NII Article ID (NAID)
    130006732099
  • Text Lang
    ENG
  • ISSN
    0917-5040
  • Data Source
    J-STAGE 
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