Association between Number of Teeth, Severe Periodontitis and Carotid Intima-media Thickness in Patients with Dyslipidemia

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  • Yutaka TERADA
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital
  • Toshiyuki NAGASAWA
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital Division of Advanced Clinical Education, Department of Integrated Dental Education, School of Dentistry, Health Sciences University of Hokkaido
  • Yumiko KONISHI
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital Division of General Dental Sciences 1, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
  • Tatsuji ODACHI
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital Division of General Dental Sciences 1, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
  • Mari MORI
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital Division of General Dental Sciences 1, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
  • Takeo MAIDA
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital Division of General Dental Sciences 2, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
  • Mitsuru MORIYA
    Division of Internal Medicine, Health Sciences University of Hokkaido Hospital Division of Internal Medicine, Department of Medicine, Institute of Personalized Medical Science, Health Sciences University of Hokkaido
  • Hajime IDE
    Division of Internal Medicine, Health Sciences University of Hokkaido Hospital
  • Masahiro TSUJI
    Division of Internal Medicine, Health Sciences University of Hokkaido Hospital Division of Internal Medicine, Department of Medicine, Institute of Personalized Medical Science, Health Sciences University of Hokkaido
  • Tomofumi KAWAKAMI
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital Division of General Dental Sciences 1, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido
  • Yasushi FURUICHI
    Division of General Dentistry, Health Sciences University of Hokkaido Hospital Division of Periodontology and Endodontology, Department of Oral Rehabilitation, School of Dentistry, Health Sciences University of Hokkaido

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  • 脂質異常症患者における残存歯数および重度歯周炎と頸動脈内中膜厚との関連性

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Abstract

<p> Purpose: This cross-sectional study investigated the association between severity of periodontal disease, dental and medical conditions, and maximum carotid intima-media thickness (max-IMT).</p><p> Methods: Fifty-two subjects with a diagnosis of dyslipidemia, receiving carotid ultrasound examination, were recruited in the study at the Health Sciences University of Hokkaido Hospital. The results of clinical dental examination (number of teeth, percentage of teeth with probing pocket depth (PPD) ≥4 mm, 6 mm, bleeding on probing sites, mean PPD, periodontal inflamed and epithelial surface area, Eichner’s index), and medical or serum lipid parameters (sex, age, smoking habit, diabetes mellitus, body mass index, total cholesterol, high-density lipoprotein (HDL), non HDL, low-density lipoprotein, triglycerides) were collected. Correlation analysis, chi-square or Fisher’s exact test and then multiple linear and binary logistic regression analyses were performed to identify factors associated with max-IMT.</p><p> Results: Regarding Spearman’s rank correlation coefficient, max-IMT was significantly associated with mean PPD, moderate and severe periodontal parameters. In the results of multiple linear regression analysis, number of teeth (partial regression coefficient (β) =−0.014, 95% confidence interval (CI) =−0.024 to −0.003, p=0.014) and HDL (β=−0.005, 95%CI=−0.008 to −0.002, p=0.003) ) were significantly associated with decreased max-IMT. In the chi-square or Fisher’s exact test, dichotomized max-IMT (≥1.1 mm and <1.1 mm) was significantly associated with the percentage of teeth with PPD≥6 mm (more than 50 versus less than 50 percentile). In the results of binary logistic regression analysis, there was a significant association between max-IMT≥1.1 mm and percentage of teeth with PPD≥6 mm (more than 50 versus less than 50 percentile) (odds ratio (OR) =8.275, 95%CI=1.462-46.844, p=0.017). The max-IMT≥1.1 mm was associated, though not significantly, with male sex (OR=4.196, 95%CI=0.914-19.252, p=0.065).</p><p> Conclusion: This study demonstrated that tooth loss or severe periodontitis was independently associated with increased max-IMT in patients with dyslipidemia.</p>

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