Design, synthesis, antifungal activity, and 3D-QSAR of coumarin derivatives
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- Wei Yan
- Research Center of Agro-bionic Engineering & Tech. of Shandong Province, College of Chemistry & Pharm, Qingdao Agricultural University
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- Peng Wei
- Laboratory for Computational Biochemistry & Molecular Design, Department of Phytomedicine, Qingdao Agricultural University School of Pharmaceutical Science and Technology, Tianjin University Department of Chemistry, China Agricultural University
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- Wang Dong
- Research Center of Agro-bionic Engineering & Tech. of Shandong Province, College of Chemistry & Pharm, Qingdao Agricultural University
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- Hao Shuang-Hong
- Research Center of Agro-bionic Engineering & Tech. of Shandong Province, College of Chemistry & Pharm, Qingdao Agricultural University
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- Li Wen-Wen
- Laboratory for Computational Biochemistry & Molecular Design, Department of Phytomedicine, Qingdao Agricultural University
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- Ding Fei
- Laboratory for Computational Biochemistry & Molecular Design, Department of Phytomedicine, Qingdao Agricultural University
Bibliographic Information
- Other Title
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- クマリン誘導体のデザイン,合成,抗菌活性および3D-QSAR
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Abstract
<p>In our research, a series of 8-substituted coumarin derivatives were synthesized, and their structures were confirmed by FT-IR, 1H-NMR, and MS (or HRMS). In activity screening, the synthesized compounds exhibited potent antifungal activity against 4 phytopathogenic fungi: Botrytis cinerea, Colletotrichum gloeosporioides, Fusarium oxysporum, and Valsa mali. Notably, 8-chloro coumarin and ethyl 8-chloro-coumarin-3-carboxylate showed the strongest fungus inhibition with EC50 of 0.085 and 0.078 mmol/L against V. mali. Furthermore, 3D-QSAR models (CoMFA and CoMSIA) of the title compounds against V. mali were established on the basis of their antifungal activities. The results indicated that the appropriate small, hydrophilic and electron-withdrawing groups on coumarin’s C-3 and C-8, respectively, could enhance the antifungal activity. The information obtained will be very helpful for designing new derivatives with high antifungal activities.</p>
Journal
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- Journal of Pesticide Science
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Journal of Pesticide Science 43 (2), 88-95, 2018-05-17
Pesticide Science Society of Japan
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Details 詳細情報について
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- CRID
- 1390282680185698048
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- NII Article ID
- 130006743011
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- NII Book ID
- AA11818622
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- ISSN
- 13490923
- 03851559
- 1348589X
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- NDL BIB ID
- 028994833
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- Text Lang
- en
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed