PARYLENE-FILM BIOACTUATOR DRIVEN BY CHICK EMBRYO CARDIOMYOCYTE

• Furuike Kaori

  Institute of Industrial Science, the University of Tokyo

• Shima Ai

  Institute of Industrial Science, the University of Tokyo

• Yoshida Shotaro

  Institute of Industrial Science, the University of Tokyo

• Morimoto Yuya

  Institute of Industrial Science, the University of Tokyo

• Takeuchi Shoji

  Institute of Industrial Science, the University of Tokyo

Bibliographic Information

Other Title

• 鶏胚由来心筋細胞駆動バイオアクチュエータの開発

Abstract

We propose a bioactuator driven by a chick embryo cardiomyocyte for the investigation of cardiomyocytes as alternatives of rodent cardiomyocytes driven actuator. Chick embryo cardiomyocytes are more accessible than rodent cardiomyocytes in terms of cost and ethics. Here, we cultured chick embryo cardiomyocytes on parylene films and observed that the edges of parylene films were autonomously lifted up and down by the contractile force of cardiomyocytes. Moreover, the frequency of flapping increased in response to the addition of isoproterenol, which promotes contraction of cardiac muscles. This bioactuator would reduce the cost of experiments and thus be expected to promote the study of contractile properties of cardiomyocytes.

Journal

• The Proceedings of the Symposium on Micro-Nano Science and Technology

  The Proceedings of the Symposium on Micro-Nano Science and Technology 2017.8 (0), PN-78-, 2017

  The Japan Society of Mechanical Engineers

Keywords

• muscle actuator
• cardiac myocyte
• chicken cardiomyocyte

Details

• CRID: 1390845712965586304
• NII Article ID: 130006745006
• DOI: 10.1299/jsmemnm.2017.8.pn-78
• ISSN: 24329495
• Web Site: https://www.jstage.jst.go.jp/article/jsmemnm/2017.8/0/2017.8_PN-78/_pdf
• Text Lang: ja
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed