Potential of Enzymomics Methodologies to Characterize Disease-Related Protein Functions

• Komatsu Toru

  The University of Tokyo Graduate School of Pharmaceutical Sciences Precursory Research for Embryonic Science and Technology (PRESTO) Investigator

抄録

Enzymatic functions are often altered during disease onset and progression, and therefore chemical–biological studies, which utilize chemical knowledge to discover novel protein functions, are often employed to find proteins with functions closely related to disease phenotypes. Such studies are known as forward chemical–biological approaches and form part of the emerging field of enzymomics (omics of enzymes). This review provides an overview of methodologies available for discovering and characterizing disease-related alterations of enzymatic functions and prospects for the future.

収録刊行物

• ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ

  ＣＨＥＭＩＣＡＬ　＆　ＰＨＡＲＭＡＣＥＵＴＩＣＡＬ　ＢＵＬＬＥＴＩＮ 65 (7), 605-610, 2017

  公益社団法人 日本薬学会

キーワード

• chemical biology
• fluorescent probe
• enzyme
• enzymomics
• peptide

詳細情報

• CRID: 1390001204178054784
• NII論文ID: 130006772511
• NII書誌ID: AA00602100
• DOI: 10.1248/cpb.c17-00144
• ISSN: 13475223
• ISSN: 00092363
• NDL書誌ID: 028312974
• PubMed: 28674330
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028312974
• Web Site: https://www.jstage.jst.go.jp/article/cpb/65/7/65_c17-00144/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018082192
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可