Serum Non-High-Density Lipoprotein Cholesterol and Risk of Cardiovascular Disease in Community Dwellers with Chronic Kidney Disease: the Hisayama Study

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Author(s)

    • Usui Tomoko
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Ninomiya Toshiharu
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University|Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
    • Nagata Masaharu
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Hata Jun
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University|Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
    • Mukai Naoko
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University|Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
    • Hirakawa Yoichiro
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University|Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University
    • Yoshida Daigo
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University|Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University
    • Kishimoto Hiro
    • Department of Epidemiology and Public Health, Graduate School of Medical Sciences, Kyushu University
    • Kitazono Takanari
    • Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University|Center for Cohort Studies, Graduate School of Medical Sciences, Kyushu University

Abstract

<p><b><i>Aim</i></b><b>: </b>It is not clear whether elevated serum non-high-density lipoprotein cholesterol (non-HDL-C) levels are a risk factor for cardiovascular disease (CVD) in subjects with chronic kidney disease (CKD) in the general population.</p><p><b><i>Methods</i></b><b>: </b>A total of 2,630 community-dwelling Japanese subjects (1,107 men and 1,523 women) without history of CVD and aged ≥40 years were prospectively followed up for an average of 19 years, and the association between serum non-HDL-C levels and the incidence of type-specific CVD was estimated using a Cox proportional hazards model. CKD was defined as estimated glomerular filtration rate <60 mL/min/1.73 m<sup>2</sup> or proteinuria (≥1+ on dipstick).</p><p><b><i>Results</i></b><b>: </b>At baseline, 357 subjects had CKD. During the follow up, 186 coronary heart disease (CHD) and 277 stroke events occurred. The age- and sex-adjusted incidence of CHD was significantly higher in subjects with higher non-HDL-C levels, both in those with and without CKD. In the CKD group, the risk of CHD was significantly higher in those with non-HDL-C levels of 150– 189 mg/dL [adjusted hazard ratio (HR), 2.23; 95% confidence interval (CI), 1.04–4.77] and those with levels ≥190 mg/dL (adjusted HR, 3.20; 95% CI, 1.46–7.03) than in those with levels <150 mg/dL. In the non-CKD group, the risk of CHD was significantly higher only in those with nonHDL-C levels ≥190 mg/dL (adjusted HR, 2.12; 95% CI, 1.33–3.38). However, no such association was observed for the risk of stroke.</p><p><b><i>Conclusions</i></b><b>: </b>Our findings suggest that higher serum non-HDL-C levels are associated with greater risk of CHD in subjects with and without CKD and that this association is greater in subjects with CKD than in those without CKD.</p>

Journal

  • Journal of Atherosclerosis and Thrombosis

    Journal of Atherosclerosis and Thrombosis 24(7), 706-715, 2017

    Japan Atherosclerosis Society

Codes

  • NII Article ID (NAID)
    130006827175
  • Text Lang
    ENG
  • ISSN
    1340-3478
  • Data Source
    J-STAGE 
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