α-galactosylceramide 付加細胞投与によるNKT 細胞活性化を介した抗腫瘍免疫療法  [in Japanese] Cancer Immunotherapy via Activation of NKT Cells by Administration of α-galactosylceramide Lorded Cells  [in Japanese]

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Author(s)

    • 西 将康 Nishi Masayasu
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 角 泰雄 Sumi Yasuo
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 中村 哲 Nakamura Tetsu
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 鈴木 知志 Suzuki Satoshi
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 掛地 吉弘 Kakeji Yoshihiro
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 山下 公大 Yamashita Kimihiro
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 長谷川 寛 Hasegawa Hiroshi
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 田中 智子 Tanaka Tomoko
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 有本 聡 Arimoto Akira
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 山本 将士 Yamamoto Masashi
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 金治 新悟 Kanaji Shingo
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 松田 佳子 Matsuda Yoshiko
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan
    • 押切 太郎 Oshikiri Taro
    • 神戸大学大学院 食道胃腸外科 Department of Surgery, Division of Gastrointestinal Surgery, Kobe University Graduate School of Medicine, Kobe, Japan

Abstract

<p>Recently, cancer immunotherapy is noticed as a new therapy of cancer, in addition to surgery, chemotherapy, and radiotherapy. We have been focused on alpha-galactosylceramide (αGalCer) loaded cell treatment, that can activate invariant NKT cell, and consequently activate both innate and acquired immunity by intravenous injection. Especially, we focus on allogeneic dendritic cells pulsed with αGalCer (DCG ) treatment because of its therapeutic efficacy. Our research clarified allogeneic DCG treatment prolonged survival similar to syngeneic DCG treatment. And also we revealed allogeneic DCG treatment induced similar antitumor effect regarding NK and NKT cell activity compared to syngeneic DCG treatment. As a result, our data shows allogeneic DCG treatment could be substituted for syngeneic DCG treatment. Furthermore, our results also show that the therapeutic value of allogeneic DCG is significantly better than syngeneic DCG in a kind of tumor cell lines. According to an examination of cytotoxic activity after treatment, this superiority would be caused by enhancement of antitumor effect with acquired immunity. We are currently working on creating therapeutic models by adopting antigen-specific T cells, and examine this enhancement.</p>

Journal

  • Cytometry Research

    Cytometry Research 27(1), 7-12, 2017

    Japan Cytometry Society

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