プレクリニカル期を対象としたAlzheimer病臨床研究
-
- 岩田 淳
- 東京大学医学部附属病院神経内科
書誌事項
- タイトル別名
-
- Clinical studies on preclinical Alzheimer's disease
この論文をさがす
抄録
<p>Although enormous efforts have been made to develop anti–amyloid therapy against mild to moderate Alzheimer's disease (AD) dementia, no single drug has succeeded in clinical trials. These failures could be attributed to 1) inaccurate clinical diagnosis, and 2) inappropriate timing for intervention. The clinical diagnosis used in previous trials are clinical criteria with low sensitivity and specificity. Thus new criteria that incorporated biomarker results has been established. In addition, various longitudinal studies revealed that Alzheimer's disease develops dementia long after it's pathological starting point where almost 15 years of asymptomatic stage precedes mild cognitive impairment (MCI) due to AD or prodromal AD. This asymptomatic stage is now called “Preclinical AD” and thought to be a promising intervention period for anti–amyloid therapy. We started an observational study in Japan which is funded by the Japan Agency for Medical Research and Development (AMED) recruiting 500 individuals in total, that follows cognition, biomarker samples, and multimodal images for 3 years. Moreover, in the US, there are multiple drug intervention studies for preclinical AD subjects. Hopefully, these efforts could help developing AD prevention.</p>
収録刊行物
-
- 神経治療学
-
神経治療学 34 (3), 283-287, 2017
日本神経治療学会
- Tweet
キーワード
詳細情報 詳細情報について
-
- CRID
- 1390001204635585024
-
- NII論文ID
- 130006846495
-
- ISSN
- 21897824
- 09168443
-
- 本文言語コード
- ja
-
- データソース種別
-
- JaLC
- CiNii Articles
- KAKEN
-
- 抄録ライセンスフラグ
- 使用不可