エマージングマテリアル・PICsome ~PEGとPEGのはざまで~  [in Japanese] An emerging material “PICsome”: A hot zone between “PEG” and “PEG”  [in Japanese]

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Author(s)

    • 岸村 顕広 Kishimura Akihiro
    • 九州大学大学院 工学研究院 応用化学部門(分子)|九州大学 分子システム科学センター Center for Molecular Systems, Kyushu University|Department of Applied Chemistry, Faculty of Engineering, Kyushu University

Abstract

ポリイオンコンプレックス形成を用いて作製する高分子ベシクルPICsomeは、水溶性のブロック共重合体を用いて水溶液中で簡便に作製できる新しいタイプの中空カプセルである。特に、荷電を持たないPEG鎖と荷電性ポリアミノ酸からなるブロック共重合体の会合状態を制御することで、DDSにも有効なサイズ域で粒径制御ができる。また、PICsomeは、内部に水相を持ちつつ、ベシクル内外での物質のやり取りを比較的自由に行えるというユニークな特徴を持つ。本稿では、PICsomeの基本的な設計法や調製法、その特徴的物性の解説に加えて、最近行われたDDSへの応用事例についても紹介させていただく。

Recently, nanomaterials constructed by molecular self-assembly have gathered much attention to develop nano-devices incorporated with many types of drugs. Particularly, hollow capsules are one of promising materials, and recently, we have developed polyion complex vesicles, PICsomes, as novel polymeric vesicles. The most advantageous feature of PICsomes is its simple preparation process: Typically, they can be prepared by simple mixing of oppositely charged block copolymers consisting of poly(ethylene glycol) (PEG) and charged poly(amino acid)s in an aqueous medium. Moreover, many other unique properties of PICsomes have been reported, such as facile tuning of vesicle sizes ranging from 100-400 nm while keeping monodispersed size distribution, semipermeable vesicle membrane, facile loading of various water-dispersed materials, long blood circulation after crosslinking, excellent tumor accumulation based on the enhanced permeability and retention (EPR) effect, and so on. The present review article describes basic design and synthetic strategy of PICsomes, fundamental properties of PICsomes, and recent applications of PICsomes to drug delivery system.

Journal

  • Drug Delivery System

    Drug Delivery System 31(4), 308-319, 2016

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

Codes

  • NII Article ID (NAID)
    130006846567
  • NII NACSIS-CAT ID (NCID)
    AN10084591
  • Text Lang
    JPN
  • ISSN
    0913-5006
  • NDL Article ID
    027669380
  • NDL Call No.
    Z19-1945
  • Data Source
    NDL  J-STAGE 
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