Urinary pH reflects dietary acid load in patients with type 2 diabetes

DOI Web Site 被引用文献3件 参考文献30件 オープンアクセス
  • Miki Akane
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
  • Hashimoto Yoshitaka
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
  • Tanaka Muhei
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
  • Kobayashi Yukiko
    Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
  • Wada Sayori
    Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
  • Kuwahata Masashi
    Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
  • Kido Yasuhiro
    Graduate School of Life and Environmental Sciences, Kyoto Prefectural University
  • Yamazaki Masahiro
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science
  • Fukui Michiaki
    Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science

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<p>Dietary acid load is important information, however, survey of food intake needs time and skill. Therefore, it is difficult to survey food intake from all patients. It remains to be elucidated the association between dietary acid load and urinary pH in patients with type 2 diabetes. In this cross-sectional study of 173 patients, we investigated the relationship between urinary pH and dietary acid load, assessed with potential renal acid load. Habitual food and nutrient intake was assessed by a self-administered diet history questionnaire. Urinary pH was negatively correlated with potential renal acid load (r = –0.24, p = 0.002). Multivariate regression analysis revealed that potential renal acid load (standardized regression coefficient = –0.21, p = 0.036) was associated with urinary pH after adjusting for covariates. In addition, according to the receiver operator characteristic analysis, the optimal cut-off point of urinary pH for high dietary acid load, defined as potential renal acid load over 7.0 mEq/day was 5.7 (area under the receiver operator characteristic curve 0.63 (95% CI 0.54–0.71), sensitivity = 0.56, specificity = 0.70, p = 0.004). Urinary pH was associated with dietary acid load in patients with type 2 diabetes. We suggest that urinary pH can be a practical screening marker for dietary acid load in patients with type 2 diabetes.</p>

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