Intake of mulberry 1-deoxynojirimycin prevents colorectal cancer in mice

• E Shuang

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Yamamoto Kazushi

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Sakamoto Yu

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Mizowaki Yui

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Iwagaki Yui

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

• Kimura Toshiyuki

  Institute of Food Research, National Agriculture and Food Research Organization (NARO)

• Nakagawa Kiyotaka

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agriculture, Tohoku University

• Miyazawa Teruo

  Food and Biodynamic Chemistry Laboratory, Graduate School of Agriculture, Tohoku University

• Tsuduki Tsuyoshi

  Laboratory of Food and Biomolecular Science, Graduate School of Agriculture, Tohoku University

Abstract

The effect of 1-deoxynojirimycin, a caloric restriction mimetic, was examined in ICR mice with azoxymethane dextran sodium sulfate-induced colorectal cancer. Azoxymethane is a carcinogen (10 mg/kg body weight), and 2% dextran sodium sulfate (w/v) used as a colitis-inducing agent. Mice were separated into 5 groups: a group without colorectal cancer fed a normal diet (CO– group), and groups with colorectal cancer fed a normal diet (CO+ group), a calorie-restricted diet (caloric restriction group), and diets including 0.02% and 0.1% 1-deoxynojirimycin (l-1-deoxynojirimycin and H-1-deoxynojirimycin groups). The tumor incidence and number were reduced significantly in the caloric restriction group compared to the CO+ group, and were also suppressed in a dose-dependent manner by 1-deoxynojirimycin. mRNA for anti-apoptotic Bcl-2 was decreased and that for pro-apoptotic Bax was increased in the carcinoma tissue of CR, l-1-deoxynojirimycin and H-1-deoxynojirimycin groups. These results suggest that caloric restriction and 1-deoxynojirimycin inhibit growth of colorectal cancer by inducing apoptosis in an induced cancer model in mice.

Journal

• Journal of Clinical Biochemistry and Nutrition

  Journal of Clinical Biochemistry and Nutrition 61 (1), 47-52, 2017

  SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Keywords

• azoxymethane
• caloric restriction
• colorectal cancer
• 1-deoxynojirimycin
• dextran sodium sulfate

Details

• CRID: 1390282679647565568
• NII Article ID: 130006847652
• DOI: 10.3164/jcbn.16-94
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/61/1/61_16-94/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2018082237
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed