動脈硬化症の臨床的研究(第2報)

• 都島 基夫

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 山村 卓

  Department of Etiology, Institute of National Cardiovascular Center

• 永田 健二

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 草竹 宏美

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 村田 朋子

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 早川 みち子

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 松下 正幸

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 本間 友基

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 六反 一仁

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 脇 昌子

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 洪 秀樹

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 西大條 靖子

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 南部 征喜

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

• 山本 章

  Department of Etiology, Institute of National Cardiovascular Center

• 中山 龍

  Department of Internal Medicine, Division of Peripheral Vascular Diseases

• 池田 正男

  Department of Internal Medicine, Division of Atherosclerosis, Metabolism and Clin. Nutrition

書誌事項

タイトル別名

• Lipid Metabolism and Apolipoprotein E Phenotype in Atherosclerosis Obliterans

抄録

In order to investigate the significance of the lipoprotein on the atherosclerosis obliterans (ASO), plasma levels of total cholesterol, triglyceride, HDL cholesterol, apolipoprotein A-I, A-II, C-II and E, lipoprotein electrophoresis, apolipoprotein E phenotype determined by analytical isoelectric focusing of the VLDL were studied in 45 ASO patients. In outpatients suffering from hyperlipoproteinemias, diabetes mellitus, hypertension, ischemic heart disease or cerebrovascular diseases, the assessment of atherosclerosis was done by the body CT scan. They were divided into two groups; 34 patients with the wall thickening of the abdominal aorta and/or common iliac artery and 39 without the stenosis of them. The stenotic group had higher arteriosclerotic calcification index, higher TG level, and lower HDL cholesterol level in comparison with the nonstenotic group. In ASO patients, increased mean cholesterol and TG levels and decreased HDL-cholesterol level were observed. Eight of 21 ASO patients had midbands in lipoprotein electrophoresis. In total, the distribution of hyperlipoproteinemias was 16% of IIa, 27% of IIb and 20% of IV or V, that is, higher incidences of IIb and IV or V compared with the healthy group. Concentrations of apo A-I and A-II were low, 117.2±18.4mg/dl and 28.7±3.6mg/dl, respectively, while apo C-II was high, 4.05±2.28mg/dl. As for the apolipoprotein E phenotype, lower frequency of E3/3 and higher in E4/3 were shown as on Table 1. Heterozygote E4/3 might have a progressive influence on the development of atherosclerosis. In conclusion, only 5 in 45 ASO patients had no abnormality such as hypercholesterolemia, hypertriglyceridemia, low HDL cholesterol, the presence of midbands in the lipoprotein electrophoresis and apoprotein abnormalities.

収録刊行物

• 動脈硬化

  動脈硬化 12 (5), 1237-1242, 1984

  一般社団法人 日本動脈硬化学会

詳細情報

• CRID: 1570854177983133568
• NII論文ID: 130006848281
• データソース種別:
  • CiNii Articles