硬化部重量比によるヒト冠動脈硬化の進行度分類

• 山田 裕

  Department of Medicine and Physical Therapy, University of Tokyo, School of Medicine

• 村田 克己

  Department of Medicine and Physical Therapy, University of Tokyo, School of Medicine

• 河野 林

  Tokyo Metropolitan Examiner's Office

書誌事項

タイトル別名

• A Classification of Atherosclerotic Extent of Human Coronary Artery

抄録

50 coronary arteries obtained from cases of accidental sudden death were studied. The intimal surface of coronary vessels was carefully sketched. For further refinement, the weight ratio of the sclerotic portion to total was calculated.<br>On the other hand, the atherosclerotic change of the left coronary artery was observed microscopically at the turning point between the anterior descending and circumflexous branches. The relative area of the lumen and the enlargement rate of the cross section area were determined by means of photographs of microscopic sections on enlarging paper. On the basis of the weight ratio of the sclerosis, the extent of coronary atherosclerosis was classified into 4 groups: normal, 0-10%; slightly sclerotic, 10-30%; moderately sclerotic, 30-60%; and severely sclerotic groups, above 60%. The lumen of normal group occupied 47% of the total cross section area of the artery. Slightly, moderately and severely sclerotic groups revealed 38%, 30% and 21%, respectively. About 10% decrements in the luminal area were found among these four groups in this order. The enlargement of cross section area was observed with the progress of atherosclerosis. The cross section area of slightly sclerotic group showed 3.3 times of that of normal arteries. Moderately and severely affected groups revealed 2.6 and 3.7 times, respectively.<br>On the peripheral portion of the coronary artery, perivascular changes were occured earlier than narrowing of the lumen. The constriction of the lumen in the peripheral portion was started when the area of the lumen revealed 20-30% of the total area in the central portion. Thus, the present classification of the extent of coronary atherosclerosis by the weight ratio of the sclerotic portion to total was supported by the microscopic observation.

収録刊行物

• 動脈硬化

  動脈硬化 7 (1), 49-54, 1979

  一般社団法人 日本動脈硬化学会

詳細情報

• CRID: 1573387452774175360
• NII論文ID: 130006849691
• データソース種別:
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