冠動脈硬化症におけるアポA-I遺伝子多型性

• 伊藤 英章

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 稲津 明広

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 松下 裕之

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 藤田 一

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 梶波 康二

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 武田 三昭

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 道下 一朗

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 嘉門 信雄

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 若杉 隆伸

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 小泉 順二

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 馬渕 宏

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

• 竹田 亮祐

  The Second Department of Internal Medicine, School of Medicine, Kanazawa University

書誌事項

タイトル別名

• Apolipoprotein A-I Gene Polymorphism in Patients with Coronary Heart Disease and Normolipidemic Controls

抄録

A low level of high-density-lipoprotein (HDL) has been reported to be a predictive indicator of coronary heart disease (CHD). Apolipoprotein A-I is a principal protein constituent of HDL and decreased apolipoprotein A-I level is also regarded as a risk factor of CHD. We studied the difference in a Restriction Fragment Length Polymorphism (RFLP) of apolipoprotein A-I gene with endonuclease Pst I digestion between 30 CHD-patients and 24 normolipidemic control groups. Using 2.2kb fragment of human apolipoprotein A-I gene as a probe, 2.2kb and 3.3kb bands were detected. There was no significant difference in the frequency of 3.3kb band between patients with CHD and controls, 0.100 and 0.063, respectively. In this study the polymorphism of apolipoprotein A-I gene is different from those reported by Ordovas. Such difference would be expected to show racial and regional influences. In Japanese population there was no significant association between this RFLP and CHD. The 24 patients with CHD were divided into two groups according to the presence or absence 3.3kb band and patients with 3.3kb band have been proved to have higher triglycerides and lower HDL cholesterol levels.

収録刊行物

• 動脈硬化

  動脈硬化 15 (7), 1521-1525, 1987

  一般社団法人 日本動脈硬化学会

詳細情報

• CRID: 1573105977803848704
• NII論文ID: 130006851179
• データソース種別:
  • CiNii Articles