糖尿病と下肢動脈石灰化

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  • Diabetes Mellitus and Arterial Calcification in the Legs

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It is thought that multi-factors may relate to the occurence and exaggeration of arterial sclerosis in diabetes mellitus. We pointed out the calcification of peripheral arteries in the legs on X-ray photographs as a sign of arteriosclerosis, and studied its prevalence in diabetics and nondiabetics. Furthermore, in order to clarify what correlates with the arteriosclerosis, we analysed the laboratory data and studied the differences between the diabetics with or without the peripheral arterial calcification.<br>We concluded that the incidence of the peripheral arterial calcification in diabetics (32%) was twofold higher than that in non-diabetics (16%).<br>It was clarified that the incidence of the calcification increased significantly in diabetics who had insulin treatment as compared with those who had oral agents or only diet therapy. Similarly, it was significantly higher in diabetics who were complicated with proliferative retinopathy than those who had simple or no retinopathy. And also, diabetics with longer duration of illness had significantly high incidence of the calcification as compared with those with shorter duration.<br>It was relatively higher frequency in diabetics who had hypertention and were controled poorly than those who had normotention and were controled well, respectively, but there was no significance between them.<br>There were no relationships between the peripheral arterial calcification and obesity, serum concentration of lipids, ischemic changes on ECG and aortic arch-calcification in diabetics.<br>These results suggested that the peripheral arterial calcification might relate to the metabolic derangement in diabetes mellitus.

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