先行する核酸アナログ製剤からテノホビルへの変更がHBs抗原量に及ぼす影響  [in Japanese] Effect of switching of previous nucleos(t)ide analogues to Tenofovir on Hepatitis B surface antigen levels  [in Japanese]

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Author(s)

    • 奥瀬 千晃 Okuse Chiaki
    • 川崎市立多摩病院(指定管理者 聖マリアンナ医科大学)消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
    • 松本 伸行 Matsumoto Nobuyuki
    • 聖マリアンナ医科大学消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
    • 高橋 秀明 Takahashi Hideaki
    • 聖マリアンナ医科大学横浜市西部病院消化器内科 Division of Gastroenterology, Department of Internal Medicine, St. Marianna University School of Medicine, Yokohama City Seibu Hospital
    • 四柳 宏 Yotsuyanagi Hiroshi
    • 東京大学医科学研究所先端医療研究センター感染症分野 Division of Infectious Disease, Advanced Clinical Research Center, Institute of Medical Science, The University of Tokyo
    • 伊東 文生 Itoh Fumio
    • 聖マリアンナ医科大学消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
    • 鈴木 通博 Suzuki Michihiro
    • 川崎市立多摩病院(指定管理者 聖マリアンナ医科大学)消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
    • 平石 哲也 Hiraishi Tetsuya
    • 川崎市立多摩病院(指定管理者 聖マリアンナ医科大学)消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
    • 石井 俊哉 Ishii Toshiya
    • 川崎市立多摩病院(指定管理者 聖マリアンナ医科大学)消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
    • 森田 望 Morita Nozomi
    • 川崎市立多摩病院(指定管理者 聖マリアンナ医科大学)消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
    • 末谷 敬吾 Suetani Keigo
    • 川崎市立多摩病院(指定管理者 聖マリアンナ医科大学)消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
    • 石郷岡 晋也 Ishigooka Shinya
    • 川崎市立多摩病院(指定管理者 聖マリアンナ医科大学)消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
    • 池田 裕喜 Ikeda Hiroki
    • 聖マリアンナ医科大学消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
    • 渡邊 綱正 Watanabe Tsunamasa
    • 聖マリアンナ医科大学消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
    • 松永 光太郎 Matsunaga Kotaro
    • 聖マリアンナ医科大学消化器・肝臓内科 Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine

Abstract

<p>Hepatitis B surface antigen (HBsAg) levels in sixteen patients who underwent switching of previous nucleos(t)ide analogues (NAs) to Tenofovir (TDF) were evaluated. Patients were classified into Adefovir (ADF)-pretreated group and Entecavir (ETV)-pretreated group. HBsAg levels were significantly decreased throughout the course, especially after administration of TDF in all patients. In ADF-pretreated group, no significant difference of HBsAg levels was observed before and after administration of TDF. On the other hand, HBsAg levels after administration of TDF were significant decreased, while no significant difference was observed before administration of TDF in ETV-pretreated group. As conclusion, it is suspected that administration of TDF may have some effect on control of HBsAg levels.</p>

Journal

  • Kanzo

    Kanzo 58(6), 354-356, 2017

    The Japan Society of Hepatology

Codes

  • NII Article ID (NAID)
    130006855887
  • Text Lang
    JPN
  • ISSN
    0451-4203
  • Data Source
    J-STAGE 
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